Prognostic Factors of Liver Transplantation for Hepatocellular Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis

被引:0
作者
Li, Jun-bo [1 ,2 ,3 ]
Zhao, Yuan-yuan [1 ,2 ,3 ]
Dai, Chen [1 ,2 ,3 ]
Chen, Dong [1 ,2 ,3 ]
Wei, Lai [1 ,2 ,3 ]
Yang, Bo [1 ,2 ,3 ]
Chen, Zhi-shui [1 ,2 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Organ Transplantat, Tongji Med Coll,Minist Educ,Natl Hlth Comm,Key Lab, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Chinese Acad Med Sci, Tongji Med Coll, Wuhan 430030, Peoples R China
基金
中国国家自然科学基金;
关键词
database analysis; cohort study; liver transplantation; organ transplantation; hepatocellular carcinoma; SEER database; MILAN CRITERIA; SURVIVAL; IMPACT; PREDICTORS; OUTCOMES; CANCER; RECURRENCE; CHILDHOOD; ETHNICITY; RESECTION;
D O I
10.1007/s11596-023-2720-y
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
ObjectiveWe aimed to identify new, more accurate risk factors of liver transplantation for liver cancer through using the Surveillance, Epidemiology, and End Results (SEER) database.MethodsUsing the SEER database, we identified patients that had undergone surgical resection for non-metastatic hepatocellular carcinoma (HCC) and subsequent liver transplantation between 2010 and 2017. Overall survival (OS) was estimated using Kaplan-Meier plotter. Cox proportional hazards regression modelling was used to identify factors independently associated with recurrent disease [presented as adjusted hazard ratios (HR) with 95% CIs].ResultsTotally, 1530 eligible patients were included in the analysis. There were significant differences in ethnicity (P=0.04), cancer stage (P<0.001), vascular invasion (P<0.001) and gall bladder involvement (P<0.001) between the groups that survived, died due to cancer, or died due to other causes. In the Cox regression model, there were no significant differences in OS at 5 years with different operative strategies (autotransplantation versus allotransplantation), nor at survival at 1 year with neoadjuvant radiotherapy. However, neoadjuvant radiotherapy did appear to improve survival at both 3 years (HR: 0.540, 95% CI: 0.326-0.896, P=0.017) and 5 years (HR: 0.338, 95% CI: 0.153-0.747, P=0.007) from diagnosis.ConclusionThis study demonstrated differences in patient characteristics between prognostic groups after liver resection and transplantation for HCC. These criteria can be used to inform patient selection and consent in this setting. Preoperative radiotherapy may improve long-term survival post-transplantation.
引用
收藏
页码:329 / 335
页数:7
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