The role of long non-coding RNA in abdominal aortic aneurysm

被引：9

作者：

Xu, Yi ^{[1
]}

Yang, Shuofei ^{[1
]}

Xue, Guanhua ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Vasc Surg, Shanghai, Peoples R China

来源：

FRONTIERS IN GENETICS | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

abdominal aortic aneurysm (AAA); epigenetic modifications; non-codingRNA; longnon-codingRNA; smooth musclecells; SMOOTH-MUSCLE-CELLS; INTRALUMINAL THROMBUS; MURAL THROMBUS; MATRIX METALLOPROTEINASES; RISK-FACTORS; APOPTOSIS; ACTIVATION; ATHEROSCLEROSIS; DIFFERENTIATION; INFLAMMASOME;

D O I：

10.3389/fgene.2023.1153899

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The abdominal aortic aneurysm (AAA) is characterized by segmental expansion of the abdominal aorta and a high mortality rate. The characteristics of AAA suggest that apoptosis of smooth muscle cells, the production of reactive oxygen species, and inflammation are potential pathways for the formation and development of AAA. Long non-coding RNA (lncRNA) is becoming a new and essential regulator of gene expression. Researchers and physicians are focusing on these lncRNAs to use them as clinical biomarkers and new treatment targets for AAAs. LncRNA studies are beginning to emerge, suggesting that they may play a significant but yet unidentified role in vascular physiology and disease. This review examines the role of lncRNA and their target genes in AAA to increase our understanding of the disease's onset and progression, which is crucial for developing potential AAA therapies.

引用

页数：11

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