A double-edged sword of platelet-derived extracellular vesicles in tissues, injury or repair: The current research overview

被引：2
作者：
Zhu, Zepeng [1 ,2 ]
Sun, Si
Jiang, Tiancheng [1 ,2 ]
Zhang, Lei [1 ,3 ,4 ]
Chen, Ming [1 ,3 ,4 ]
Chen, Shuqiu [1 ,3 ,4 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Dept Urol, Nanjing, Peoples R China
[2] Southeast Univ, Med Sch, Nanjing, Peoples R China
[3] Southeast Univ, Inst Urol, Med Sch, Surg Res Ctr, Nanjing, Peoples R China
[4] Southeast Univ, Zhongda Hosp, Dept Urol, 87 Dingjiaqiao Hunan Rd, Nanjing 210009, Peoples R China
来源：
TISSUE & CELL | 2023年 / 82卷
关键词：
Extracellular vesicles (EVs); Exosomes; Microvesicles; Platelet; -derived; PEVs; Function; LIVER-REGENERATION; RICH PLASMA; ENDOTHELIAL-CELLS; CYTOKINE STORM; STEM-CELLS; MICROPARTICLES; EXOSOMES; INFLAMMATION; PROMOTE; MICROVESICLES;
D O I：
10.1016/j.tice.2023.102066
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Extracellular vesicles (EVs) are vesicular bodies with a double-layered membrane structure that are detached from the cell membrane or secreted by the cells. EVs secreted by platelets account for the main part in the blood circulation, which account for about 30% or even more. Many types of cells are regulated by PEVs, including endothelial cells, leukocytes, smooth muscle cells, etc. Nevertheless, despite the growing interest in the study of extracellular vesicles, there are still only a few studies on the role of PEVs. Therefore, this overview mainly focuses on one method of isolation and the functions of PEVs in tissues found so far, including promoting tissue repair and mediating tissue damage, which can be used for researchers to continue to explore the role of PEVs in other fields.
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页数：7
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