Polyetheretherketone microspheres loaded with cerium dioxide nanoparticles mitigate damage from cellular oxidative stress and promote bone repair

被引：7

作者：

Li, Haoyu ^{[1
,3
]}

Wang, Zongliang ^{[3
]}

Song, Qingxu ^{[1
,3
]}

Guo, Min ^{[3
]}

Jiao, Zixue ^{[3
]}

Wang, Yu ^{[3
]}

Liu, Yi ^{[1
]}

Zhu, Yongzhan ^{[2
]}

Zhang, Peibiao ^{[3
]}

机构：

[1] First Hosp Jilin Univ, Dept Spine Surg, Changchun 130021, Peoples R China

[2] Foshan Hosp Tradit Chinese Med, Dept Orthopaed 8, Foshan 528000, Peoples R China

[3] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

来源：

MATERIALS & DESIGN | 2023年 / 225卷

基金：

中国国家自然科学基金;

关键词：

Polyetheretherketone; Cerium dioxide nanoparticles; Antioxidant; Bone regeneration; OXIDE; BIOMATERIALS; MEMBRANES; TISSUE; FORCE;

D O I：

10.1016/j.matdes.2022.111426

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The imbalance of oxidative and antioxidant effects in the bone repair process can lead to insufficient osseointegration of orthopedic implants and cause failure regeneration. In this study, cerium (IV) sulfate (Ce(SO4)2) was introduced into polyetheretherketone (PEEK) to prepare composite microspheres containing Ce(SO4)2 (Ce(SO4)2/PEEK microspheres). A hydrolysis method assisted by hydrothermal treatment enabled the successful in-situ convertion of Ce(SO4)2 to cerium dioxide nanoparticles (CeO2NPs) which were uniformly loaded in the microspheres and fulfilled a unique "topological" structure on the surface of the microspheres. In addition, CeO2NPs in the PEEK microspheres had catalase-like activity, which reduced the amount of hydrogen peroxide (H2O2) in the micro-environment of bone injury. Concurrently, the CeO2NPs/PEEK microspheres directly promoted cell proliferation and osteogenic differ-entiation and showed excellent promotion of bone regeneration in a rat-skull-defect repair model. In summary, we prepared CeO2NPs that were uniformly distributed in PEEK microspheres using a hydrothermal method to act as antioxidants and improve the osteogenic activity of PEEK microspheres. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：14