The Impact of Recombinant Human Erythropoietin Administration in Critically ill COVID-19 Patients: A Multicenter Cohort Study

被引：0

作者：

Al Sulaiman, Khalid ^{[1
,2
,3
,4
,19
]}

Aljuhani, Ohoud ^{[5
]}

Korayem, Ghazwa B. ^{[6
]}

Altebainawi, Ali F. ^{[7
,8
]}

Vishwakarma, Ramesh ^{[9
]}

AlFaifi, Mashael ^{[10
]}

Alsohimi, Samiah ^{[11
,12
]}

Alrayes, Aljoharah ^{[6
]}

Albishi, Sara ^{[6
]}

Alqahtani, Reem ^{[6
]}

Alalawi, Mai ^{[13
,14
]}

Al Sulaihim, Ibrahim ^{[15
]}

Alanazi, Thamer A. ^{[16
]}

Alqahtani, Rahaf A. ^{[1
]}

Almagthali, Alaa ^{[12
]}

Jomah, Shahamah ^{[17
]}

Alshlowi, Areej ^{[18
]}

Alshammari, Tahani R. ^{[7
]}

Alzahrani, Shahad S. ^{[2
]}

Abdulqader, Marwa I. ^{[2
]}

机构：

[1] Pharmaceut Care Dept, King Abdulaziz Med City, Riyadh, Saudi Arabia

[2] King Saud bin Abdulaziz Univ Hlth Sci, Coll Pharm, Riyadh, Saudi Arabia

[3] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[4] Saudi Crit Care Pharm Res SCAPE Platform, Riyadh, Saudi Arabia

[5] King Abdulaziz Univ, Fac Pharm, Dept Pharm Practice, Jeddah, Saudi Arabia

[6] Princess Nourah bint Abdulrahman Univ, Coll Pharm, Dept Pharm Practice, Riyadh, Saudi Arabia

[7] King Salman Specialist Hosp, Pharmaceut Care Serv, Hail Hlth Cluster, Minist Hlth, Hail, Saudi Arabia

[8] Univ Hail, Coll Pharm, Dept Clin Pharm, Hail, Saudi Arabia

[9] Univ East Anglia, Norwich Med Sch, Norwich, England

[10] Pharmaceut Care Dept, King Saud Med City, Riyadh, Saudi Arabia

[11] King Fahad Armed Forces Hosp, Pharmaceut Care Serv, Jeddah, Saudi Arabia

[12] King Abdulaziz Univ Hosp, Pharmaceut Care Serv, Jeddah, Saudi Arabia

[13] Fakeeh Coll Med Sci, Dept Pharmaceut Sci, Jeddah, Saudi Arabia

[14] Pharmaceut Care Dept, King Abdulaziz Med City, Jeddah, Saudi Arabia

[15] Cent Secur Hosp, Pharmaceut Care Dept, Presidency State Secur, Riyadh, Saudi Arabia

[16] Resp Therapy Dept, King Abdulaziz Med City, Riyadh, Saudi Arabia

[17] Pharmaceut Care Dept, Dr Sulaiman Al Habib Med Grp, Riyadh, Saudi Arabia

[18] Almaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh, Saudi Arabia

[19] King Saud bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, King Abdulaziz Med City KAMC, Minist Natl Guard Hlth Affairs MNGHA, POB 22490, Riyadh 11426, Saudi Arabia

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2023年 / 29卷

关键词：

critically ill; COVID-19; erythropoietin-stimulating agents; ESA; length of stay; mortality; ventilator-free days (VFDs);

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of erythropoietin-stimulating agents (ESAs) as adjunctive therapy in critically ill patients with COVID-19 may have a potential benefit. This study aims to evaluate the effect of ESAs on the clinical outcomes of critically ill COVID-19 patients. A multicenter, retrospective cohort study was conducted from 01-03-2020 to 31-07-2021. We included adult patients who were >= 18 years old with a confirmed diagnosis of COVID-19 infection and admitted to intensive care units (ICUs). Patients were categorized depending on ESAs administration during their ICU stay. The primary endpoint was the length of stay; other endpoints were considered secondary. After propensity score matching (1:3), the overall included patients were 120. Among those, 30 patients received ESAs. A longer duration of ICU and hospital stay was observed in the ESA group (beta coefficient: 0.64; 95% CI: 0.31-0.97; P = < .01, beta coefficient: 0.41; 95% CI: 0.12-0.69; P = < .01, respectively). In addition, the ESA group's ventilator-free days (VFDs) were significantly shorter than the control group. Moreover, patients who received ESAs have higher odds of liver injury and infections during ICU stay than the control group. The use of ESAs in COVID-19 critically ill patients was associated with longer hospital and ICU stays, with no survival benefits but linked with lower VFDs.

引用

页数：10

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