Mechanical forces and the 3D genome

被引：1

作者：

Shivashankar, G., V ^{[1
,2
]}

机构：

[1] Swiss Fed Inst Technol, Zurich, Switzerland

[2] Paul Scherrer Inst, Villigen, Switzerland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2023年 / 83卷

基金：

瑞士国家科学基金会;

关键词：

RNA-POLYMERASE-II; FOLDING PRINCIPLES; PHASE-SEPARATION; GENE-EXPRESSION; ORGANIZATION; REVEALS;

D O I：

10.1016/j.sbi.2023.102728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their sur-rounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and gene expression programs. Understanding the mechanical control of genome organization and expression may provide a new perspective on gene regulation.

引用

页数：7

共 70 条

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