Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications

被引：3
作者：
Saeidi, Hamidreza [1 ,6 ]
Bakrin, Ikmal Hisyam [2 ]
Raju, Chandramathi Samudi [3 ]
Ismail, Patimah [1 ]
Saraf, Mohsen [4 ,7 ]
Khairul-Asri, Mohd Ghani [5 ]
机构：
[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang, Malaysia
[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Pathol, Serdang, Malaysia
[3] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur, Malaysia
[4] Univ Isfahan, Fac Engn, Dept Biomed Engn, Esfahan, Iran
[5] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Urol, Serdang, Selangor, Malaysia
[6] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia
[7] Univ Isfahan, Fac Engn, Dept Biomed Engn, Azadi Sq, Esfahan 8174673441, Iran
来源：
ADVANCES IN MEDICAL SCIENCES | 2023年 / 68卷 / 02期
关键词：
Prostate cancer; Homologous recombination repair; Therapeutics; Prognostic; PLATINUM-BASED CHEMOTHERAPY; GERMLINE MUTATIONS; BRCA1; MUTATIONS; RISK; VARIANTS; ATM; MEN; THERAPIES; GENOMICS; OUTCOMES;
D O I：
10.1016/j.advms.2023.09.008
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Prostate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibitors. Moreover, it has been shown that platinum-based chemotherapy is more effective in mCRPC patients with HRR gene alterations. This review highlights the prognosis and therapeutic implications of HRR gene alterations in PC.
引用
收藏
页码：359 / 365
页数：7
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