Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?

被引:1
作者
Gong, Hang [1 ]
Xu, Hui-Mei [1 ]
Ma, Yao-Hui [1 ]
Zhang, De-Kui [1 ]
机构
[1] Lanzhou Univ, Dept Gastroenterol, Hosp 2, Lanzhou, Gansu, Peoples R China
关键词
Histone lactylation; Lactate; Glycolysis; Liver cancer; Tumorigenicity;
D O I
10.1016/j.phrs.2023.106869
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells
    Yamashita, Taro
    Kaneko, Shuichi
    [J]. JOURNAL OF GASTROENTEROLOGY, 2014, 49 (07) : 1105 - 1110
  • [42] Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells
    Taro Yamashita
    Shuichi Kaneko
    [J]. Journal of Gastroenterology, 2014, 49 : 1105 - 1110
  • [43] Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications
    Marquardt, J. U.
    Factor, V. M.
    Thorgeirsson, S. S.
    [J]. JOURNAL OF HEPATOLOGY, 2010, 53 (03) : 568 - 577
  • [44] Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells
    Wuputra K.
    Lin C.-S.
    Tsai M.-H.
    Ku C.-C.
    Lin W.-H.
    Yang Y.-H.
    Kuo K.-K.
    Yokoyama K.K.
    [J]. Inflammation and Regeneration, 37 (1)
  • [45] Effects of quantum dots on the ROS amount of liver cancer stem cells
    Li, Kunmeng
    Xia, Chunhui
    Wang, Baiqi
    Chen, Hetao
    Wang, Tong
    He, Qian
    Cao, Hailong
    Wang, Yu
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 155 : 193 - 199
  • [46] Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells
    Shi, Lei
    Li, Bowen
    Tan, Jiyu
    Zhu, Ling
    Zhang, Sicheng
    Zhang, Yuhan
    Xiang, Meng
    Li, Jie
    Chen, Yan
    Han, Xue
    Xie, Jiacheng
    Tang, Yao
    Xing, H. Rosie
    Li, Jingyu
    Wang, Jianyu
    [J]. JOURNAL OF NANOBIOTECHNOLOGY, 2025, 23 (01)
  • [47] Evaluating the immortal strand hypothesis in cancer stem cells: Symmetric/self-renewal as the relevant surrogate marker of tumorigenicity
    Winquist, Raymond J.
    Hall, Amy B.
    Eustace, Brenda K.
    Furey, Brinley F.
    [J]. BIOCHEMICAL PHARMACOLOGY, 2014, 91 (02) : 129 - 134
  • [48] Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution
    Yun, Jun-Won
    Ahn, Jae Hun
    Kwon, Euna
    Kim, Seung-Hyun
    Kim, Hanna
    Jang, Ja-June
    Kim, Woo Ho
    Kim, Ji Hyang
    Han, Su-youne
    Kim, Jin Tac
    Kim, Jong-Hoon
    Kim, Wookhwan
    Ku, Seung-Yup
    Do, Byung-Rok
    Kang, Byeong-Cheol
    [J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2016, 81 : 437 - 447
  • [49] Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype
    Jiang, J.
    Zhang, Y.
    Chuai, S.
    Wang, Z.
    Zheng, D.
    Xu, F.
    Zhang, Y.
    Li, C.
    Liang, Y.
    Chen, Z.
    [J]. ONCOGENE, 2012, 31 (06) : 671 - 682
  • [50] Biology and clinical implications of CD133+ liver cancer stem cells
    Ma, Stephanie
    [J]. EXPERIMENTAL CELL RESEARCH, 2013, 319 (02) : 126 - 132