Dynamic Evolution of SARS-CoV-2 in a Patient on Chemotherapy

被引：0

作者：

Huang, Weihua ^{[1
]}

Yin, Changhong ^{[1
]}

Briley, Kimberly P. ^{[1
]}

Dalzell, William A. B. ^{[2
]}

Fallon, John T. ^{[1
]}

机构：

[1] East Carolina Univ, Brody Sch Med, Dept Pathol & Lab Med, Greenville, NC 27834 USA

[2] East Carolina Univ, Brody Sch Med, Dept Pediat, Greenville, NC 27834 USA

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 08期

关键词：

SARS-CoV-2; COVID-19; deletion; evolution; chemotherapy;

D O I：

10.3390/v15081759

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved significantly during the pandemic and resulted in daunting numbers of genomic sequences. Tracking SARS-CoV-2 evolution during persistent cases could provide insight into the origins and dynamics of new variants. We report here a case of B-cell acute lymphocytic leukemia on chemotherapy with infection of SARS-CoV-2 for more than two months. Genomic surveillance of his serial SARS-CoV-2-positive specimens revealed two unprecedented large deletions, ?15-26 and ?138-145, in the viral spike protein N-terminal domain (NTD) and demonstrated their dynamic shifts in generating these new variants. Located at antigenic supersites, these large deletions are anticipated to dramatically change the spike protein NTD in three-dimensional protein structure prediction, which may lead to immune escape but reduce their viral transmissibility. In summary, we present here a new viral evolutionary trajectory in a patient on chemotherapy.

引用

页数：8

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