SIRT1 and SIRT6: The role in aging-related diseases

被引：37

作者：

You, Yuzi ^{[1
]}

Liang, Wei ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Urol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai 200025, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2023年 / 1869卷 / 07期

关键词：

Sirtuins; SIRT1; SIRT6; Aging; Aging-related diseases; HISTONE DEACETYLASE SIRT6; FOAM CELL-FORMATION; OXIDATIVE STRESS; PROTEIN-KINASE; CANCER-CELLS; DNA-REPAIR; MITOCHONDRIAL SIRTUINS; GLUCOSE-HOMEOSTASIS; GENOMIC INSTABILITY; CALORIC RESTRICTION;

D O I：

10.1016/j.bbadis.2023.166815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1-7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels. We also discuss the therapeutic potential of SIRT1 and SIRT6 modulators in the treatment of these diseases and challenges thereof.

引用

页数：10

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