Indium mediated barbier-type allylation: Synthesis of highly functionalized homoallylic difluorohydrins

被引：2

作者：

Wu, Jihong ^{[1
]}

Wang, Yanzhao ^{[1
]}

Wang, Junqi ^{[1
]}

Huang, Jinwen ^{[1
]}

Li, Ruowen ^{[1
]}

Wang, Kaiji ^{[1
]}

Wu, Zhuo ^{[1
]}

Wu, Fanhong ^{[1
]}

机构：

[1] Shanghai Inst Technol, Shanghai Engn Res Ctr Green Fluoropharmaceut Techn, Shanghai 201418, Peoples R China

来源：

TETRAHEDRON | 2023年 / 140卷

基金：

中国国家自然科学基金;

关键词：

Indium mediated allylation; Allyl substituted halodifluoromethylation; Halogenated difluoromethylation reagents; Synthetic methods; CARBONYL-COMPOUNDS; ALDEHYDES; REAGENTS; ALCOHOLS; KETONES; DIFLUOROACETYLTRIALKYLSILANES;

D O I：

10.1016/j.tet.2023.133385

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indium-mediated Barbier-type allylation of halogenated difluoroacetophenone is reported for the first time. This method can directly and conveniently access homoallylic difluorohydrin alcohol blocks from halogenated difluoroacetophenones, and has good functional group compatibility. As a novel difluoromethylation reagent, the block has potential in the synthesis of fluorinated compounds.& COPY; 2023 Published by Elsevier Ltd.

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页数：4

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