Impact of SARS-CoV-2 Omicron and Delta variants in patients requiring intensive care unit (ICU) admission for COVID-19, Northern Italy, December 2021 to January 2022

被引：10

作者：

Piralla, Antonio ^{[1
]}

Mojoli, Francesco ^{[2
,3
]}

Pellegrinelli, Laura ^{[4
]}

Ceriotti, Ferruccio ^{[5
]}

Valzano, Antonia ^{[5
]}

Grasselli, Giacomo ^{[6
]}

Gismondo, Maria Rita ^{[7
]}

Micheli, Valeria ^{[7
]}

Castelli, Antonio ^{[8
]}

Farina, Claudio ^{[9
]}

Arosio, Marco ^{[9
]}

Lorini, Ferdinando Luca ^{[10
]}

Fanti, Diana ^{[11
]}

Busni, Andrea ^{[11
]}

Laratta, Matteo ^{[12
]}

Maggi, Fabrizio ^{[13
]}

Novazzi, Federica ^{[13
]}

Cabrini, Luca ^{[14
]}

Callegaro, Anna Paola ^{[15
]}

Keim, Roberto ^{[16
]}

Remuzzi, Giuseppe ^{[17
]}

Cavallero, Annalisa ^{[18
]}

Malandrin, Sergio Maria Ivano ^{[18
]}

Rona, Roberto ^{[19
]}

Giardina, Federica ^{[1
]}

Ferrari, Guglielmo ^{[1
]}

Zavaglio, Federica ^{[1
]}

D'angelo, Piera ^{[1
]}

Galli, Cristina ^{[4
]}

Bubba, Laura ^{[4
]}

Binda, Sandro ^{[4
]}

Oggioni, Massimo ^{[5
]}

Renteria, Sara Colonia Uceda ^{[5
]}

Bono, Patrizia ^{[5
]}

Baj, Andreina ^{[13
]}

Ferrante, Francesca Drago ^{[13
]}

Guarneri, Davide ^{[12
]}

Tonelli, Marco ^{[12
]}

Napolitano, Gavino ^{[9
]}

Nava, Alice ^{[11
]}

Romeo, Lorenzo ^{[20
]}

Nicolini, Elena ^{[20
]}

Valaperta, Rea ^{[15
]}

Varisano, Ludovica ^{[15
]}

Mele, Caterina ^{[21
]}

Liguori, Lucia ^{[21
]}

Raggi, Monica ^{[18
]}

Mongodi, Silvia ^{[2
]}

Pagani, Michele ^{[2
]}

Severgnini, Paolo ^{[22
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Microbiol & Virol Dept, Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Anaesthesia & Intens Care, Pavia, Italy

[3] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

[4] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[5] Fdn IRCCS CaGranda Osped Maggiore Policlin, Clin Lab, Milan, Italy

[6] Osped Maggiore Policlin, Fdn IRCCS CaGranda, Dept Anesthesia Crit Care & Emergency, Milan, Italy

[7] ASST Fatebenefratelli Sacco, Lab Clin Microbiol Virol & Bioemergencies, Milan, Italy

[8] ASST Fatebenefratelli Sacco, Div Anesthesiol & Intens Care, Milan, Italy

[9] ASST Papa Giovanni XXIII, Microbiol & Virol Lab, Bergamo, Italy

[10] ASST Papa Giovanni XXIII, Dept Emergency & ICU, Bergamo, Italy

[11] ASST Grande Osped Metropolitano Niguarda, Lab Clin Microbiol, Milan, Italy

[12] Univ Milano Bicocca, Intens Care Osped Niguarda, Dept Anesthesia, Milan, Italy

[13] Univ Insubria, Dept Med & Surg, Varese, Italy

[14] Osped Circolo & Fdn Macchi, Intens Care & Anesthesia Unit, Varese, Italy

[15] ASST Bergamo Est, Lab Med Unit, Seriate, Italy

[16] ASST Bergamo Est, Intens Care Unit, Seriate, Italy

[17] Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy

[18] Microbiol Lab San Gerardo Hosp, Monza, Italy

[19] San Gerardo Hosp ASST Monza, Dept Anesthesia & Intens Care Med, Monza, Italy

[20] Univ Milan, Residency Microbiol & Virol, Milan, Italy

[21] Ist di Ric Farmacol Mario Negri IRCCS, Lab Immunol & Genet Rare Dis, Milan, Italy

[22] Univ Insubria, Osped Circolo & Fdn Macchi, Dept Biotechnol & Life, Varese, Italy

[23] Direz Gen Welf, Milan, Reg Lombardia, Italy

来源：

RESPIRATORY MEDICINE AND RESEARCH | 2023年 / 83卷

关键词：

SARS-CoV-2; Intensive care unit (ICU); Severe infections; COVID-19; Omicron variant; Delta variant; Variant of Concern (VOC); Italy; DISEASE SEVERITY;

D O I：

10.1016/j.resmer.2023.100990

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

This multicenter observational study included 171 COVID-19 adult patients hospitalized in the ICUs of nine hospitals in Lombardy (Northern Italy) from December, 1st 2021, to February, 9th 2022. During the study period, the Delta/Omicron variant ratio of cases decreased with a delay of two weeks in ICU patients com-pared to that in the community; a higher proportion of COVID-19 unvaccinated patients was infected by Delta than by Omicron whereas a higher rate of COVID-19 boosted patients was Omicron-infected. A higher number of comorbidities and a higher comorbidity score in ICU critically COVID-19 inpatients was positively associated with the Omicron infection as well in vaccinated individuals. Although people infected by Omi-cron have a lower risk of severe disease than those infected by Delta variant, the outcome, including the risk of ICU admission and the need for mechanical ventilation due to infection by Omicron versus Delta, remains uncertain. The continuous monitoring of the circulating SARS-CoV-2 variants remains a milestone to counter-act this pandemic.(c) 2023 SPLF and Elsevier Masson SAS. All rights reserved.

引用

页数：5

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