Pathogenicity and virulence of Aspergillus fumigatus

被引：42

作者：

Earle, Kayleigh ^{[1
]}

Valero, Clara ^{[1
]}

Conn, Daniel P. P. ^{[2
]}

Vere, George ^{[2
]}

Cook, Peter C. C. ^{[2
]}

Bromley, Michael J. J. ^{[1
]}

Bowyer, Paul ^{[1
]}

Gago, Sara ^{[1
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Manchester Fungal Infect Grp, Manchester, England

[2] Univ Exeter, MRC Ctr Med Mycol, Exeter, England

来源：

VIRULENCE | 2023年 / 14卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Aspergillus fumigatus; Aspergillosis; Virulence factors; Pathogenicity; at-risk factors; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; INVASIVE PULMONARY ASPERGILLOSIS; TRANSMEMBRANE CONDUCTANCE REGULATOR; NF-KAPPA-B; EXTRACELLULAR-MATRIX PROTEINS; AIRWAY MUCUS HYPERSECRETION; CYSTIC-FIBROSIS; INNATE IMMUNE; DENDRITIC CELLS; HOST-DEFENSE;

D O I：

10.1080/21505594.2023.2172264

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences arising from immunosuppression, chronic respiratory conditions or more recently, concomitant viral or bacterial pulmonary infections are recognised risks factors for the development of pulmonary aspergillosis. In this review, we will summarise our current knowledge of the mechanistic basis of pulmonary aspergillosis with a focus on emerging at-risk populations.

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页数：35

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