New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline

被引:7
作者
Deng, Hongting [1 ]
He, Yuanju [1 ]
Cao, Hui [1 ]
Chen, Lei [1 ]
Teng, Hui [1 ]
机构
[1] Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Guangdong Prov Engn Technol Res Ctr Seafood, Coll Food Sci & Technol,Guangdong Prov Key Lab Aqu, Zhanjiang, Peoples R China
来源
FOOD FRONTIERS | 2023年 / 4卷 / 01期
关键词
cytotoxicity; flavonoids; heterocyclic amine; hydroxyl substitution; myricetin; POLYPHENOLS; QUERCETIN; AMINES;
D O I
10.1002/fft2.194
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The aim of the present work was to evaluate different structures of flavonoids interfering with the cytotoxicity of heterocyclic amines (HCA). Eight flavonoids with similar structure including myricetin, rutin, fisetin, quercetin, myricetrin, quercetrin, kaempferol, and galangin were coincubated with 2-amino-4-methylimidazo[4,5-f]quinolone (IQ) respectively to determine the cytotoxicity. The results revealed that IQ at low doses showed no cytotoxicity; however, in the presence of myricetin and rutin, the cytotoxicity significantly elevated. It seems that C-3 ', C-4 ', C-5 ', and C-5 hydroxyl substituents on the flavonoid skeleton of B ring play important role in the increasing cytotoxicity induced by IQ in HepG2 cells. Interestingly, the data obtained from the present study revealed an unexpected adverse effect of the supposed beneficial food ingredient myricetin, which appears to be able to increase the cytotoxicity of the procarcinogen HCA.
引用
收藏
页码:289 / 296
页数:8
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