Tropical cyclones (TCs) are the most devastating weather phenomena that trigger massive loss of property and life in the coastal areas of the Bay of Bengal (BoB). Scientific understanding of TC occurrence can aid policy-makers and residents in coastal areas to take the necessary actions and do appropriate planning in advance. In this study, we aimed to examine the possible linkage of weather parameters with the deadly 22 TC events in the BoB from 1975 to 2014 using principal component analysis, K-mean clustering, and general circulation model (GCMs). Results showed that among 22 TCs, cluster 1 belongs to 12 TCs that occurred under the same atmospheric situation when the sea level pressure (SLP) was below 990 hPa, and the temperature ranged from 30 to 39 degrees C. A deep negative anomaly in SLP and temperature was observed up to 500 hPa levels. In contrast, a negative depression was found at 300 hPa geopotential height (GPH) over the study area. Cluster 2 consisted of 9 TCs when SLP was below 1000 hPa, and the average temperature was 33.5 degrees C. A strong negative anomaly was noticed at surface level up to 500 hPa GPH, but dramatically, this depression was completely absent at 300 hPa geopotential height over the BoB and entire coastal region. Cluster 3 contained only 1 TC when the atmospheric circumstances were completely diverse, and the SLP was above 1000 hPa. The results of the GCM model revealed that the SLP was lower, and the temperature was higher over BoB compared to the North Indian Ocean. We identified the larger depression of SLP and unpredictable temperature anomalies in the upper atmosphere that can trigger enormous unpredictability throughout the atmospheric level, leading to severe TCs. The outcomes of this study can improve our understanding of weather variables in the upper atmospheric column for forecasting the TC system more accurately in the future.