A SILICON NEURAL PROBE MONOLITHICALLY INTEGRATED WITH 20 μM-PITCHED DUAL-COLOR MICRO-LED ARRAYS

被引：0

作者：

Mao, Dacheng ^{[1
]}

Sun, Feng ^{[1
]}

Driscoll, Bradley ^{[2
]}

Li, Zhihao ^{[1
]}

Xu, Guangyu ^{[1
,3
]}

机构：

[1] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Psychol & Brain Sci, Amherst, MA 01003 USA

[3] Univ Massachusetts, Dept Biomed Engn, Amherst, MA 01003 USA

来源：

2024 IEEE 37TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS | 2024年

基金：

美国国家科学基金会;

关键词：

optoelectronics; neuroengineering; optogenetics; brain science; electrophysiology; INTERROGATION; CIRCUITS;

D O I：

10.1109/MEMS58180.2024.10439308

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Optogenetics is a powerful neuromodulation strategy that features temporal precision, cell-type specificity, and bi-directionality (i.e. the capability to excite and inhibit the same neurons via different colors of light). Limited by feasible integration methods, neural probes integrated with arrays of dual-color light sources remain underdeveloped, hindering bidirectional optogenetic control of brain activity with high spatial resolutions. Here we report, based on heterogeneously stacked III-V films, the first silicon neural probe monolithically integrated with 20-mu m pitched dual-color micro-LED arrays, which enabled depth-dependent bi-directional in vivo optogenetic electrophysiology for the first time.

引用

页码：421 / 424

页数：4

共 18 条

[1] Millisecond-timescale, genetically targeted optical control of neural activity [J].

Boyden, ES ;

Zhang, F ;

Bamberg, E ;

Nagel, G ;

Deisseroth, K .

NATURE NEUROSCIENCE, 2005, 8 (09) :1263-1268

[2] Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo [J].

Canales, Andres ;

Jia, Xiaoting ;

Froriep, Ulrich P. ;

Koppes, Ryan A. ;

Tringides, Christina M. ;

Selvidge, Jennifer ;

Lu, Chi ;

Hou, Chong ;

Wei, Lei ;

Fink, Yoel ;

Anikeeva, Polina .

NATURE BIOTECHNOLOGY, 2015, 33 (03) :277-+

[3] Optogenetics: 10 years of microbial opsins in neuroscience [J].

Deisseroth, Karl .

NATURE NEUROSCIENCE, 2015, 18 (09) :1213-1225

[4] Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks [J].

English, Daniel Fine ;

McKenzie, Sam ;

Evans, Talfan ;

Kim, Kanghwan ;

Yoon, Euisik ;

Buzsaki, Gyorgy .

NEURON, 2017, 96 (02) :505-+

[5] Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex [J].

Kapfer, Christoph ;

Glickfeld, Lindsey L. ;

Atallah, Bassam V. ;

Scanziani, Massimo .

NATURE NEUROSCIENCE, 2007, 10 (06) :743-753

[6] Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe [J].

Li, Lizhu ;

Lu, Lihui ;

Ren, Yuqi ;

Tang, Guo ;

Zhao, Yu ;

Cai, Xue ;

Shi, Zhao ;

Ding, He ;

Liu, Changbo ;

Cheng, Dali ;

Xie, Yang ;

Wang, Huachun ;

Fu, Xin ;

Yin, Lan ;

Luo, Minmin ;

Sheng, Xing .

NATURE COMMUNICATIONS, 2022, 13 (01)

[7] Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical-hippocampal interactions [J].

Liu, Xin ;

Ren, Chi ;

Lu, Yichen ;

Liu, Yixiu ;

Kim, Jeong-Hoon ;

Leutgeb, Stefan ;

Komiyama, Takaki ;

Kuzum, Duygu .

NATURE NEUROSCIENCE, 2021, 24 (06) :886-896

[8] Single-Cell Optogenetic Control of Calcium Signaling with a High-Density Micro-LED Array [J].

Mao, Dacheng ;

Li, Ningwei ;

Xiong, Zheshun ;

Sun, Yubing ;

Xu, Guangyu .

ISCIENCE, 2019, 21 :403-+

[9] High Density, Double-sided, Flexible Optoelectronic Neural Probes With Embedded μLEDs [J].

Reddy, Jay W. ;

Kimukin, Ibrahim ;

Stewart, Luke T. ;

Ahmed, Zabir ;

Barth, Alison L. ;

Towe, Elias ;

Chamanzar, Maysamreza .

FRONTIERS IN NEUROSCIENCE, 2019, 13

[10] NEURONAL CIRCUITS IN BARREL CORTEX FOR WHISKER SENSORY PERCEPTION [J].

Staiger, Jochen F. ;

Petersen, Carl C. H. .

PHYSIOLOGICAL REVIEWS, 2021, 101 (01) :353-415

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