Molecular mechanisms of ferroptosis in cardiovascular disease

被引：3
作者：
Zeng, Qun [1 ]
Jiang, Tingting [2 ]
机构：
[1] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2024年 / 479卷 / 12期
关键词：
Cardiovascular disease; Ferroptosis; Lipid peroxides; Metabolism; LIPID-PEROXIDATION; MITOCHONDRIAL; INHIBITION; INJURY; DEATH; ACSL4; GENE;
D O I：
10.1007/s11010-024-04940-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ferroptosis is a newly recognized type of regulated cell death that is characterized by the accumulation of iron and lipid peroxides in cells. Studies have shown that ferroptosis plays a significant role in the pathogenesis of various diseases, including cardiovascular diseases. In cardiovascular disease, ferroptosis is associated with ischemia-reperfusion injury, myocardial infarction, heart failure, and atherosclerosis. The molecular mechanisms underlying ferroptosis include the iron-dependent accumulation of lipid peroxidation products, glutathione depletion, and dysregulation of lipid metabolism, among others. This review aims to summarize the current knowledge of the molecular mechanisms of ferroptosis in cardiovascular disease and discuss the potential therapeutic strategies targeting ferroptosis as a treatment for cardiovascular disease.
引用
收藏
页码：3181 / 3193
页数：13
相关论文
共 110 条
[11]   The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis [J].
Bersuker, Kirill ;
Hendricks, Joseph M. ;
Li, Zhipeng ;
Magtanong, Leslie ;
Ford, Breanna ;
Tang, Peter H. ;
Roberts, Melissa A. ;
Tong, Bingqi ;
Maimone, Thomas J. ;
Zoncu, Roberto ;
Bassik, Michael C. ;
Nomura, Daniel K. ;
Dixon, Scott J. ;
Olzmann, James A. .
NATURE, 2019, 575 (7784) :688-+
[12]   Resveratrol and Cardiovascular Diseases [J].
Bonnefont-Rousselot, Dominique .
NUTRIENTS, 2016, 8 (05)
[13]   Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression [J].
Cardoso, Alisson C. ;
Lam, Nicholas T. ;
Savla, Jainy J. ;
Nakada, Yuji ;
Pereira, Ana Helena M. ;
Elnwasany, Abdallah ;
Menendez-Montes, Ivan ;
Ensley, Emily L. ;
Petric, Ursa Bezan ;
Sharma, Gaurav ;
Sherry, A. Dean ;
Malloy, Craig R. ;
Khemtong, Chalermchai ;
Kinter, Michael T. ;
Tan, Wilson Lek Wen ;
Anene-Nzelu, Chukwuemeka G. ;
Foo, Roger Sik-Yin ;
Ngoc Uyen Nhi Nguyen ;
Li, Shujuan ;
Ahmed, Mahmoud Salama ;
Elhelaly, Waleed M. ;
Abdisalaam, Salim ;
Asaithamby, Aroumougame ;
Xing, Chao ;
Kanchwala, Mohammed ;
Vale, Gonalo ;
Eckert, Kaitlyn M. ;
Mitsche, Matthew A. ;
McDonald, Jeffrey G. ;
Hill, Joseph A. ;
Huang, Linzhang ;
Shaul, Philip W. ;
Szweda, Luke, I ;
Sadek, Hesham A. .
NATURE METABOLISM, 2020, 2 (02) :167-+
[14]   Defining a Healthy Diet: Evidence for the Role of Contemporary Dietary Patterns in Health and Disease [J].
Cena, Hellas ;
Calder, Philip C. .
NUTRIENTS, 2020, 12 (02)
[15]   Mitochondrial Dynamics and Its Involvement in Disease [J].
Chan, David C. .
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020, 2020, 15 :235-259
[16]   Ferroptosis in infection, inflammation, and immunity [J].
Chen, Xin ;
Kang, Rui ;
Kroemer, Guido ;
Tang, Daolin .
JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (06)
[17]   Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice [J].
Chen, Yonger ;
Li, Cantao ;
Duan, Shuni ;
Yuan, Xin ;
Liang, Jian ;
Hou, Shaozhen .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 118
[18]   Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways [J].
Chen, Yuqiong ;
Li, Su ;
Yin, Ming ;
Li, Yafei ;
Chen, Chao ;
Zhang, Jun ;
Sun, Kangyun ;
Kong, Xiangqing ;
Chen, Zhangwei ;
Qian, Juying .
DIABETES, 2023, 72 (03) :389-404
[19]   The Role of Ferroptosis in Cardiovascular Disease and Its Therapeutic Significance [J].
Chen, Zhenzhen ;
Yan, Youyou ;
Qi, Chao ;
Liu, Jia ;
Li, Longbo ;
Wang, Junnan .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8
[20]   NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis [J].
Dodson, Matthew ;
Castro-Portuguez, Raul ;
Zhang, Donna D. .
REDOX BIOLOGY, 2019, 23
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