Molecular mechanisms of ferroptosis in cardiovascular disease

被引：3

作者：

Zeng, Qun ^{[1
]}

Jiang, Tingting ^{[2
]}

机构：

[1] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2024年 / 479卷 / 12期

关键词：

Cardiovascular disease; Ferroptosis; Lipid peroxides; Metabolism; LIPID-PEROXIDATION; MITOCHONDRIAL; INHIBITION; INJURY; DEATH; ACSL4; GENE;

D O I：

10.1007/s11010-024-04940-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis is a newly recognized type of regulated cell death that is characterized by the accumulation of iron and lipid peroxides in cells. Studies have shown that ferroptosis plays a significant role in the pathogenesis of various diseases, including cardiovascular diseases. In cardiovascular disease, ferroptosis is associated with ischemia-reperfusion injury, myocardial infarction, heart failure, and atherosclerosis. The molecular mechanisms underlying ferroptosis include the iron-dependent accumulation of lipid peroxidation products, glutathione depletion, and dysregulation of lipid metabolism, among others. This review aims to summarize the current knowledge of the molecular mechanisms of ferroptosis in cardiovascular disease and discuss the potential therapeutic strategies targeting ferroptosis as a treatment for cardiovascular disease.

引用

页码：3181 / 3193

页数：13

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