Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group

被引：1

作者：

Luedersen, Jette ^{[1
]}

Stadt, Udo zur ^{[2
,3
]}

Richter, Julia ^{[4
]}

Oschlies, Ilske ^{[4
]}

Klapper, Wolfram ^{[4
]}

Rosenwald, Andreas ^{[5
]}

Kalinova, Marketa ^{[6
,7
,8
,9
]}

Simonitsch-Klupp, Ingrid ^{[10
]}

Siebert, Reiner ^{[11
,12
]}

Zimmermann, Martin ^{[13
,14
]}

Qi, Minyue ^{[15
]}

Nakel, Jacqueline ^{[16
]}

Scheinemann, Katrin ^{[17
,18
,19
,20
]}

Knoerr, Fabian ^{[1
,21
]}

Attarbaschi, Andishe ^{[22
,23
]}

Kabickova, Edita ^{[24
,25
]}

Woessmann, Wilhelm ^{[1
,26
]}

Damm-Welk, Christine ^{[1
,26
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Paediat Haematol & Oncol & NHL BFM Study Ctr, Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Paediat Haematol & Oncol, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, CoALL Study Ctr, Hamburg, Germany

[4] Univ Hosp Schleswig Holstein, Dept Pathol, Haematopathol Sect & Lymph Node Registry, Kiel, Germany

[5] Univ Wurzburg, Dept Pathol, Wurzburg, Germany

[6] Charles Univ Prague, Fac Med 2, Dept Pathol & Mol Med, Prague, Czech Republic

[7] Univ Hosp Motol, Prague, Czech Republic

[8] Charles Univ Prague, Fac Med 3, Dept Pathol, Prague, Czech Republic

[9] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic

[10] Med Univ Vienna, Dept Pathol, Vienna, Austria

[11] Ulm Univ, Inst Human Genet, Ulm, Germany

[12] Ulm Univ Med Ctr, Ulm, Germany

[13] Hannover Med Sch, Dept Paediat Haematol & Oncol, Hannover, Germany

[14] BFM Study Ctr, NHL, Hannover, Germany

[15] Univ Med Ctr Hamburg Eppendorf, Bioinformat Core, Hamburg, Germany

[16] Leibniz Inst Virol LIV, Hamburg, Germany

[17] Childrens Hosp Eastern Switzerland, Div Paediat Haematol Oncol, St Gallen, Switzerland

[18] Univ Lucerne, Fac Hlth Sci & Med, Luzern, Switzerland

[19] McMaster Childrens Hosp, Dept Paediat, Hamilton, ON, Canada

[20] McMaster Univ, Hamilton, ON, Canada

[21] Univ Med Ctr Hamburg Eppendorf, Mildred Scheel Canc Career Ctr HaTriCS4, Hamburg, Germany

[22] Med Univ Vienna, St Anna Childrens Hosp, Dept Paediat Haematol & Oncol, Vienna, Austria

[23] St Anna Childrens Canc Res Inst, Vienna, Austria

[24] Charles Univ Prague, Dept Pediat Hematol & Oncol, Prague, Czech Republic

[25] Univ Hosp Motol, Prague, Czech Republic

[26] Univ Med Ctr Hamburg Eppendorf, Paediat Haematol & Oncol, Martinistr 52, D-20246 Hamburg, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期

关键词：

ALK positive ALCL; non-Hodgkin's lymphoma; variant ALK; ORGANIZATION; DISEASE; GENE;

D O I：

10.1111/bjh.19308

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non-NPM1::ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK-positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK-partners are rare and potentially associated with different prognoses.

引用

页码：1894 / 1898

页数：5

共 23 条

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