Computational and experimental analysis of catalyst-free and expeditious synthesis of Benzo[4,5]imidazo[2,1-b]thiazole derivatives

被引：4

作者：

Singh, Ruby ^{[1
]}

Singh, Aman ^{[1
]}

Bhardwaj, Diksha ^{[2
]}

Sharma, Shobhana ^{[2
]}

机构：

[1] Jaipur Natl Univ, Sch Basic Sci, Dept Chem, Jaipur, Rajasthan, India

[2] SS Jain Subodh PG Coll, Dept Chem, Jaipur, India

来源：

JOURNAL OF SULFUR CHEMISTRY | 2024年 / 45卷 / 01期

关键词：

Benzo[4,5]imidazo[2,1-b]thiazole; catalyst-free; 2,2,2-trifluoroethanol; DFT studies; greener approach; CYCLOADDITION REACTION; HETEROCYCLES; FUNCTIONALIZATION; SOLVENT; HYBRIDS; DESIGN;

D O I：

10.1080/17415993.2023.2266083

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A greener and direct approach to the efficient synthesis of fused heterocyclic ring system benzo[4,5]imidazo[2,1-b]thiazoles via C-N and C-S bond formation in catalyst-free conditions has been reported using 2,2,2-trifluoroethanol (TFE) as a reaction medium at room temperature. The salient features of this approach include an elementary and clean reaction protocol to afford the desired product in higher yields in less reaction time with sufficient purity. This prominent moiety is frequently found in many natural bioactive occurring compounds and shows potential in synthesizing diverse biologically active compounds due to their therapeutic values. The synthesis of benzo[4,5]imidazo[2,1-b]thiazoles was confirmed by spectral analysis and also by DFT studies. GRAPHICAL ABSTRACT

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页码：1 / 11

页数：11

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