Comparison of the effects of vitamin D and nasal calcitonin spray with nasal calcitonin spray on postoperative abdominal pain: A randomised controlled trial

Background: Postoperative pain control is critical after abdominal surgery. primary researches suggest that vitamin D and nasal calcitonin spray may have an effect in reducing postoperative pain. Objective: This study aims to compare postoperative abdominal pain, in patients who received a combination of Nasocalcin spray and vitamin D to those who received Nasocalcin spray.Methods: In this double-blind randomized clinical trial, 34 patient candidates for abdominal surgery were selected. They were randomly divided into 2 groups (group A (N = 17) received vitamin D and Nasocalcin spray, and group B (N = 17) received Nasocalcin spray). The drugs have been administered to patients 1 h before surgery. Equivalent amounts of Nasocalcin and intramuscular distilled water were administered to the calcitonin group. after the surgery Patients" pain levels were measured using a visual analog scale (VAS) after they had gained full consciousness and 6, 12, and 24 h after surgery. the amount of narcotics injected in the first 24 h after surgery was monitored and compared between the two groups. Results: There was no significant relation between the groups in terms of age (p = 0.98), gender distribution (p = 0.1), surgery duration (p = 0.35), and pain scores after surgery (p = 0.67). In comparison to group B, at 6 h (p = 0.007), 12 h (p = 0.001), and 24 h (p = 0.003), group A reported significantly less pain. There was a significant reduction in total narcotic injected (p = 0.003) in group A. Conclusions: Preoperative administration of vitamin D with nasal calcitonin spray improved postoperative pain control compared to nasal calcitonin. This non-opioid drug combination represents a preemptive medication for enhanced recovery after abdominal surgery.