LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

被引：7
作者：
Zhang, Zaibo [1 ]
Li, Yong [1 ]
Fan, Liqiao [1 ]
Wang, Bingyu [1 ]
Liu, Wenbo [1 ]
Cui, Jiaxiang [1 ]
Tan, Bibo [1 ,2 ]
机构：
[1] Hebei Med Univ, Dept Gen Surg, Hosp 4, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
[2] Hebei Key Lab Precis Diag & Comprehens Treatment G, 12 Hlth Rd, Shijiazhuang 050011, Peoples R China
来源：
ISCIENCE | 2023年 / 26卷 / 09期
关键词：
PATHOGENIC ROLES; LUNG-CANCER; PROGRESSION; PROLIFERATION; CELLS;
D O I：
10.1016/j.isci.2023.107673
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies of their mechanisms of action are needed to determine their clinical value. The aim of this study is to explore the effects and mechanisms of THUMPD3-AS1 in GC. Elevated levels of THUMPD3-AS1 were observed in GC and demonstrated a significant positive correlation with poor prognosis. Functionally, THUMPD3-AS1 promoted GCcell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297. Further investigations confirmed that both THUMPD3-AS1 and miR-1297 interact with BCAT1. These findings suggest that THUMPD3-AS1 promotes GC invasion and EMT by regulating the miR-1297/BCAT1 pathway, indicating that THUMPD3-AS1 may serve as a biomarker and therapeutic target for GC.
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页数：17
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