Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias

被引：0

作者：

Prough, Michael B. ^{[1
]}

Zaman, Andrew ^{[1
]}

Caywood, Laura J. ^{[1
]}

Clouse, Jason E. ^{[1
]}

Herington, Sharlene D. ^{[1
]}

Slifer, Susan H. ^{[1
]}

Dorfsman, Daniel A. ^{[1
]}

Adams, Larry A. ^{[1
]}

Laux, Renee A. ^{[3
]}

Song, Yeunjoo E. ^{[3
]}

Lynn, Audrey ^{[3
]}

Fuzzell, Denise ^{[3
]}

Fuzzell, Sarada L. ^{[3
]}

Miller, Sherri D. ^{[3
]}

Miskimen, Kristy ^{[3
]}

Main, Leighanne R. ^{[4
,6
]}

Osterman, Michael D. ^{[3
,6
]}

Ogrocki, Paula ^{[5
,7
]}

Lerner, Alan J. ^{[5
,7
]}

Vance, Jeffery M. ^{[1
,2
]}

Haines, Jonathan L. ^{[3
,6
]}

Scott, William K. ^{[1
,2
]}

Pericak-Vance, Margaret ^{[1
,2
]}

Cuccaro, Michael L. ^{[1
,2
,8
]}

机构：

[1] Univ Miami, John P Hussman Inst Human Genom, Miller Sch Med, Miami, FL USA

[2] Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miller Sch Med, Miami, FL USA

[3] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Sch Med, Cleveland, OH USA

[4] Case Western Reserve Univ, Dept Genet & Genome Sci, Sch Med, Cleveland, OH USA

[5] Case Western Reserve Univ, Dept Neurol, Sch Med, Cleveland, OH USA

[6] Case Western Reserve Univ, Cleveland Inst Computat Biol, Cleveland, OH USA

[7] Univ Hosp Cleveland Med Ctr, Dept Neurol, Cleveland, OH USA

[8] Univ Miami, John P Hussman Inst Human Genom, Dept Human Genet Psychol, Miller Sch Med, Miami, FL 33136 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2023年 / 37卷 / 03期

关键词：

visuospatial memory; Alzheimer Disease; Amish; verbal memory; SEX-DIFFERENCES; PHYSICAL-ACTIVITY; CERAD; HERITABILITY; CONSORTIUM; EDUCATION; ESTABLISH; REGISTRY; LINKAGE; BATTERY;

D O I：

10.1097/WAD.0000000000000570

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Verbal and visuospatial memory impairments are common to Alzheimer disease and Related Dementias (ADRD), but the patterns of decline in these domains may reflect genetic and lifestyle influences. The latter may be pertinent to populations such as the Amish who have unique lifestyle experiences. Methods: Our data set included 420 Amish and 401 CERAD individuals. Sex-adjusted, age-adjusted, and education-adjusted Z-scores were calculated for the recall portions of the Constructional Praxis Delay (CPD) and Word List Delay (WLD). ANOVAs were then used to examine the main and interaction effects of cohort (Amish, CERAD), cognitive status (case, control), and sex on CPD and WLD Z-scores. Results: The Amish performed better on the CPD than the CERAD cohort. In addition, the difference between cases and controls on the CPD and WLD were smaller in the Amish and Amish female cases performed better on the WLD than the CERAD female cases. Discussion: The Amish performed better on the CPD task, and ADRD-related declines in CPD and WLD were less severe in the Amish. In addition, Amish females with ADRD may have preferential preservation of WLD. This study provides evidence that the Amish exhibit distinct patterns of verbal and visuospatial memory loss associated with aging and ADRD.

引用

页码：195 / 199

页数：5

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