Efficacy of Sildenafil in Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

被引:4
作者
Dillon, Kacie [1 ]
Lamba, Vineet [1 ]
Philip, Ranjit R. [2 ]
Weems, Mark F. [1 ]
Talati, Ajay J. [1 ]
机构
[1] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Div Neonatal Perinatal Med, Memphis, TN 38163 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Div Pediat Cardiol, Memphis, TN 38163 USA
来源
CHILDREN-BASEL | 2023年 / 10卷 / 08期
关键词
bronchopulmonary dysplasia; BPD; pulmonary hypertension; sildenafil; CHILDREN;
D O I
10.3390/children10081397
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Pulmonary hypertension (PH) is a common comorbidity in infants with bronchopulmonary dysplasia (BPD). Sildenafil is a widely recognized therapy for PH, but its efficacy in infants with BPD is questionable. We propose to assess the efficacy of sildenafil in BPD-associated PH as evaluated based on transthoracic echocardiography (TTE) changes and clinical measures. Methods: Data were retrospectively and prospectively collected. Inclusion criteria were gestational age (GA) < 32 weeks, birth weight (BW) < 1500 g with severe BPD, diagnosis of PH via TTE on sildenafil treatment. PH was evaluated via TTE, which was performed monthly after 36 weeks post-menstrual age (PMA) as a standard of care, and re-reviewed by a single pediatric cardiologist, who was blind to the initial reading. Results: In total, 19 patients were enrolled in the study, having a median GA of 24 3/7 weeks (IQR 23 5/7-25 5/7) and a median BW of 598 g (IQR 572-735). Sildenafil treatment was started at a median PMA of 40.4 weeks. The median respiratory severity score (RSS) at 28 d was 6.5, RSS and FiO2 showed improvement about 12 weeks after starting sildenafil treatment. Conclusions: Improvement in PH was noted via TTE, and patients had improvement in their RSS and FiO2 after prolonged therapy. However, TTE improvements did not correlate with clinical improvements.
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页数:9
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