The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics

被引:8
作者
Noguchi-Shinohara, Moeko [1 ]
Ono, Kenjiro [1 ]
机构
[1] Kanazawa Univ, Dept Neurol, Grad Sch Med Sci, Kanazawa 9208640, Japan
基金
日本学术振兴会;
关键词
alpha-synuclein; amyloid-beta; tau protein; aggregation; Lewy body diseases; Parkinson's disease; dementia with Lewy bodies; PHENOLIC-COMPOUNDS PREVENT; SLEEP BEHAVIOR DISORDER; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID; MOUSE MODEL; ALZHEIMERS-DISEASE; MONOCLONAL-ANTIBODY; DEMENTIA; DIAGNOSIS; PROGRESSION;
D O I
10.3390/ijms241210215
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lewy body diseases (LBD) are pathologically defined as the accumulation of Lewy bodies composed of an aggregation of alpha-synuclein (aSyn). In LBD, not only the sole aggregation of alpha Syn but also the co-aggregation of amyloidogenic proteins, such as amyloid-beta (A beta) and tau, has been reported. In this review, the pathophysiology of co-aggregation of aSyn, A beta, and tau protein and the advancement in imaging and fluid biomarkers that can detect aSyn and co-occurring A beta and/or tau pathologies are discussed. Additionally, the alpha Syn-targeted disease-modifying therapies in clinical trials are summarized.
引用
收藏
页数:16
相关论文
共 109 条
[11]   In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease [J].
Chahine, Lana M. ;
Beach, Thomas G. ;
Brumm, Michael C. ;
Adler, Charles H. ;
Coffey, Christopher S. ;
Mosovsky, Sherri ;
Caspell-Garcia, Chelsea ;
Serrano, Geidy E. ;
Munoz, David G. ;
White, Charles L., III ;
Crary, John F. ;
Jennings, Danna ;
Taylor, Peggy ;
Foroud, Tatiana ;
Arnedo, Vanessa ;
Kopil, Catherine M. ;
Riley, Lindsey ;
Dave, Kuldip D. ;
Mollenhauer, Brit .
NEUROLOGY, 2020, 95 (09) :E1267-E1284
[12]  
Chatterjee Koustav, 2020, J Neuroimmunol, V338, P577089, DOI 10.1016/j.jneuroim.2019.577089
[13]   Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia [J].
Chiasserini, Davide ;
Biscetti, Leonardo ;
Eusebi, Paolo ;
Salvadori, Nicola ;
Frattini, Giulia ;
Simoni, Simone ;
De Roeck, Naomi ;
Tambasco, Nicola ;
Stoops, Erik ;
Vanderstichele, Hugo ;
Engelborghs, Sebastiaan ;
Mollenhauer, Brit ;
Calabresi, Paolo ;
Parnetti, Lucilla .
ALZHEIMERS RESEARCH & THERAPY, 2017, 9
[14]   Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy [J].
Chouliaras, Leonidas ;
Thomas, Alan ;
Malpetti, Maura ;
Donaghy, Paul ;
Kane, Joseph ;
Mak, Elijah ;
Savulich, George ;
Prats-Sedano, Maria A. ;
Heslegrave, Amanda J. ;
Zetterberg, Henrik ;
Su, Li ;
Rowe, James Benedict ;
O'Brien, John Tiernan .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2022, :651-658
[15]  
Clinical Trials Gov, US
[16]   The Genetic Basis of Cognitive impairment and Dementia in Parkinson's Disease [J].
Collins, Lucy M. ;
Williams-Gray, Caroline H. .
FRONTIERS IN PSYCHIATRY, 2016, 7
[17]   Confluence of α-Synuclein, Tau, and β-Amyloid Pathologies in Dementia With Lewy Bodies [J].
Colom-Cadena, Marti ;
Gelpi, Ellen ;
Charif, Sara ;
Belbin, Olivia ;
Blesa, Rafael ;
Marti, Maria J. ;
Clarimon, Jordi ;
Lleo, Alberto .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2013, 72 (12) :1203-1212
[18]   Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease [J].
Compta, Yaroslau ;
Valente, Tony ;
Saura, Josep ;
Segura, Barbara ;
Iranzo, Alex ;
Serradell, Monica ;
Junque, Carme ;
Tolosa, Eduard ;
Valldeoriola, Francesc ;
Munoz, Esteban ;
Santamaria, Joan ;
Camara, Ana ;
Fernandez, Manel ;
Fortea, Juan ;
Buongiorno, Mariateresa ;
Luis Molinuevo, Jose ;
Bargallo, Nuria ;
Jose Marti, Maria .
JOURNAL OF NEUROLOGY, 2015, 262 (02) :294-306
[19]   Different species of α-synuclein oligomers induce calcium influx and seeding [J].
Danzer, Karin M. ;
Haasen, Dorothea ;
Karow, Anne R. ;
Moussaud, Simon ;
Habeck, Matthias ;
Giese, Armin ;
Kretzschmar, Hans ;
Hengerer, Bastian ;
Kostka, Marcus .
JOURNAL OF NEUROSCIENCE, 2007, 27 (34) :9220-9232
[20]   The Parkinson Pandemic-A Call to Action [J].
Dorsey, E. Ray ;
Bloem, Bastiaan R. .
JAMA NEUROLOGY, 2018, 75 (01) :9-10