Connecting the dots in the associations between diet, obesity, cancer, and microRNAs

被引:13
作者
Otsuka, Kurataka [1 ,2 ,3 ,4 ]
Nishiyama, Hiroshi [2 ]
Kuriki, Daisuke [2 ]
Kawada, Naoki [2 ]
Ochiya, Takahiro [3 ]
机构
[1] Tokyo Univ Agr, Tokyo NODAI Res Inst, 1-1-1 Sakuragaoka,Setagaya, Tokyo 1568502, Japan
[2] Kewpie Corp, R&D Div, 2-5-7 Sengawa Cho, Chofu, Tokyo 1820002, Japan
[3] Tokyo Med Univ, Inst Med Sci, Div Mol & Cellular Med, 6-7-1, Nishishinjyuku,Shinjuku Ku, Tokyo 1600023, Japan
[4] Natl Canc Ctr, Div Mol & Cellular Med, 5-1-1 Tsukiji,Chuo ku, Tokyo 1040045, Japan
关键词
Obesity; Cancer; Diet; MicroRNA; Health; STAGE; 2001-2009; FINDINGS; BODY-MASS INDEX; HUMAN BREAST-CANCER; UNITED-STATES; TUMOR-SUPPRESSOR; ADIPOSE-TISSUE; CIRCULATING MICRORNAS; ENDOMETRIAL CANCER; METABOLIC SYNDROME; COLORECTAL-CANCER;
D O I
10.1016/j.semcancer.2023.05.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The prevalence of obesity has reached pandemic levels worldwide, leading to a lower quality of life and higher health costs. Obesity is a major risk factor for noncommunicable diseases, including cancer, although obesity is one of the major preventable causes of cancer. Lifestyle factors, such as dietary quality and patterns, are also closely related to the onset and development of obesity and cancer. However, the mechanisms underlying the complex association between diet, obesity, and cancer remain unclear. In the past few decades, microRNAs (miRNAs), a class of small non-coding RNAs, have been demonstrated to play critical roles in biological processes such as cell differentiation, proliferation, and metabolism, highlighting their importance in disease development and suppression and as therapeutic targets. miRNA expression levels can be modulated by diet and are involved in cancer and obesity-related diseases. Circulating miRNAs can also mediate cell-to-cell communications. These multiple aspects of miRNAs present challenges in understanding and integrating their mechanism of action. Here, we introduce a general consideration of the associations between diet, obesity, and cancer and review the current knowledge of the molecular functions of miRNA in each context. A comprehensive understanding of the interplay between diet, obesity, and cancer could be valuable for the development of effective preventive and therapeutic strategies in future.
引用
收藏
页码:52 / 69
页数:18
相关论文
共 50 条
  • [31] Diet, physical activity, obesity and related cancer risk: strategies to reduce cancer burden in the Americas
    Stern, Mariana C.
    Barnoya, Joaquin
    Elder, John P.
    Gallegos-Carrillo, Katia
    SALUD PUBLICA DE MEXICO, 2019, 61 (04): : 448 - 455
  • [32] Associations between coronary heart disease, obesity and histological prostate cancer
    Konstantinos N. Stamatiou
    Alevizos G. Alevizos
    Konstantinos Mihas
    Anargiros D. Mariolis
    Emmanuel Michalodimitrakis
    Fragiskos Sofras
    International Urology and Nephrology, 2007, 39 : 197 - 201
  • [33] Associations between coronary heart disease, obesity and histological prostate cancer
    Stamatiou, Konstantinos N.
    Alevizos, Alevizos G.
    Mihas, Konstantinos
    Mariolis, Anargiros D.
    Michalodimitrakis, Emmanuel
    Sofras, Fragiskos
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2007, 39 (01) : 197 - 201
  • [34] Associations of changes in physical activity and diet with incident obesity and changes in adiposity: Longitudinal findings from the UK Biobank
    Ahmadi, Matthew N.
    Inan-Eroglu, Elif
    Mishra, Gita D.
    Salis, Amanda
    Stamatakis, Emmanuel
    PREVENTIVE MEDICINE, 2023, 168
  • [35] Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations
    Nikoletta Mili
    Stavroula A. Paschou
    Dimitrios G. Goulis
    Meletios-Athanasios Dimopoulos
    Irene Lambrinoudaki
    Theodora Psaltopoulou
    Endocrine, 2021, 74 : 478 - 497
  • [36] Exosome-Derived microRNAs: Bridging the Gap Between Obesity and Type 2 Diabetes in Diagnosis and Treatment
    Vukelic, Iva
    Susa, Branislav
    Klobucar, Sanja
    Buljevic, Suncica
    Prso, Ana-Marija Liberati
    Belancic, Andrej
    Rahelic, Dario
    Detel, Dijana
    DIABETOLOGY, 2024, 5 (07): : 706 - 724
  • [37] Associations of Sleep with Food Cravings, Diet, and Obesity in Adolescence
    Kracht, Chelsea L.
    Chaput, Jean-Philippe
    Martin, Corby K.
    Champagne, Catherine M.
    Katzmarzyk, Peter T.
    Staiano, Amanda E.
    NUTRIENTS, 2019, 11 (12)
  • [38] ASSOCIATIONS BETWEEN FOOD INSECURITY, DIET AND OBESITY AMONG THE AUSTRALIAN POPULATION
    Ramsey, R.
    Gallegos, D.
    ANNALS OF NUTRITION AND METABOLISM, 2013, 63 : 964 - 964
  • [39] Diet and cancer prevention: Dietary compounds, dietary MicroRNAs, and dietary exosomes
    Banikazemi, Zarrin
    Haji, Hemat Aghagolzadeh
    Mohammadi, Mohsen
    Taheripak, Gholamreza
    Iranifar, Elmira
    Poursadeghiyan, Mohsen
    Moridikia, Abdullah
    Rashidi, Bahman
    Taghizadeh, Mohsen
    Mirzaei, Hamed
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (01) : 185 - 196
  • [40] Associations between external eating cues, diet history and weight history in French subjects with obesity
    Ducy, Emilie
    Romon, Monique
    Amouyel, Philippe
    Meirhaeghe, Aline
    APPETITE, 2025, 207