Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin

被引：31

作者：

Kanwugu, Osman N. ^{[1
,2
,3
]}

Glukhareva, Tatiana V. ^{[3
]}

机构：

[1] Macquarie Univ, Sch Nat Sci, Sydney, NSW 2109, Australia

[2] Macquarie Univ, ARC Ctr Excellence Synthet Biol, Sydney, NSW 2109, Australia

[3] Ural Fed Univ, Inst Chem Engn, Mira St 28, Ekaterinburg 620002, Russia

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2023年 / 741卷

关键词：

Antioxidant; Carotenoid; Free radicals; Keap1; Natural product; Redox homeostasis; Xanthophyll; ANTIOXIDANT RESPONSE ELEMENT; TRANSCRIPTION FACTOR NRF2; NF-KAPPA-B; SIGNALING PATHWAY; NUCLEAR TRANSLOCATION; EXPRESSION; KEAP1; MODULATION; CELLS; PHOSPHORYLATION;

D O I：

10.1016/j.abb.2023.109601

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Astaxanthin, a red-orange liposoluble carotenoid, has been the centre of considerable attention in recent years for its numerous biological activities, notably its potent antioxidant activity. It is reported that astaxanthin elicits these biological activities via a number of cellular pathways. The Nrf2/Keap1 pathway is a major regulator of the antioxidant defence system of cells; it modulates the expression of a plethora of genes related to redox homeostasis as well as cellular detoxification. The pathway has received lots of attention as a prospective therapeutic target for diseases related to oxidative stress and inflammation. Several reports have shown that the pathway is inducible by many natural compounds. This present work reviews the Nrf2/Keap1 pathway, its regulation and involvement in diseases, provides a brief overview of naturally occurring compounds as activators of the pathway as well as discusses the effect of astaxanthin on the pathway.

引用

页数：15

共 170 条

[1] Melatonin as a potential modulator of Nrf2 [J].

Ahmadi, Zahra ;

Ashrafizadeh, Milad .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2020, 34 (01) :11-19

[2] Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice [J].

Aleksunes, Lauren M. ;

Reisman, Scott A. ;

Yeager, Ronnie L. ;

Goedken, Michael J. ;

Klaassen, Curtis D. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 333 (01) :140-151

[3] Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications-A Review [J].

Ambati, Ranga Rao ;

Phang, Siew Moi ;

Ravi, Sarada ;

Aswathanarayana, Ravishankar Gokare .

MARINE DRUGS, 2014, 12 (01) :128-152

[4] Phosphorylation of nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells [J].

Apopa, Patrick L. ;

He, Xiaoqing ;

Ma, Qiang .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2008, 22 (01) :63-76

[5]

Asker D, 2018, METHODS MOL BIOL, V1852, P171, DOI 10.1007/978-1-4939-8742-9_10

[6] Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-κB pathways [J].

Bao, Liping ;

Li, Jushuang ;

Zha, Dongqing ;

Zhang, Lian ;

Gao, Ping ;

Yao, Tao ;

Wu, Xiaoyan .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 54 :245-253

[7]

Basak P, 2017, TOXICOL REP, V4, P306, DOI 10.1016/j.toxrep.2017.06.002

[8] Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation [J].

Bellanti, Francesco ;

di Bello, Giorgia ;

Iannelli, Giuseppina ;

Pannone, Giuseppe ;

Pedicillo, Maria Carmela ;

Boulter, Luke ;

Lu, Wei-Yu ;

Tamborra, Rosanna ;

Villani, Rosanna ;

Vendemiale, Gianluigi ;

Forbes, Stuart J. ;

Serviddio, Gaetano .

NPJ REGENERATIVE MEDICINE, 2021, 6 (01)

[9] Nrf2-Keap1 signaling in oxidative and reductive stress [J].

Bellezza, Ilaria ;

Giambanco, Ileana ;

Minelli, Alba ;

Donato, Rosario .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2018, 1865 (05) :721-733

[10] Epidemiology of malaria in the Papua New Guinean highlands [J].

Betuela, Inoni ;

Maraga, Seri ;

Hetzel, Manuel W. ;

Tandrapah, Tony ;

Sie, Albert ;

Yala, Simon ;

Kundi, Julius ;

Siba, Peter ;

Reeder, John C. ;

Mueller, Ivo .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2012, 17 (10) :1181-1191

← 1 2 3 4 5 6 7 8 9 10 →