Putting aging on ICE

被引：1
作者：
Teefy, Bryan B. [1 ]
Benayoun, Berenice A. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
[2] USC Dornsife Coll Letters Arts & Sci, Mol & Computat Biol Dept, Los Angeles, CA 90089 USA
[3] USC Keck Sch Med, Biochem & Mol Med Dept, Los Angeles, CA 90089 USA
[4] USC Norris Comprehens Canc Ctr, Epigenet & Gene Regulat, Los Angeles, CA 90089 USA
[5] USC Stem Cell Initiat, Los Angeles, CA 90089 USA
来源：
CELL METABOLISM | 2023年 / 35卷 / 03期
关键词：
CHROMATIN;
D O I：
10.1016/j.cmet.2023.02.012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A recent report by Yang et al. in Cell demonstrates that faithful DNA double-strand breaks and repair cycles phenocopy many aspects of aging in mice. Whether this progeroid phenotype is caused by a loss of epige-netic information remains to be conclusively determined.
引用
收藏
页码：383 / 385
页数：3
相关论文
共 10 条
  • [1] Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    Berkovich, Elijahu
    Monnat, Raymond J., Jr.
    Kastan, Michael B.
    [J]. NATURE CELL BIOLOGY, 2007, 9 (06) : 683 - U137
  • [2] Chromatin and nucleosome dynamics in DNA damage and repair
    Hauer, Michael H.
    Gasser, Susan M.
    [J]. GENES & DEVELOPMENT, 2017, 31 (22) : 2204 - 2221
  • [3] Dynamic stem cell selection safeguards the genomic integrity of the epidermis
    Kato, Tomoki
    Liu, Nan
    Morinaga, Hironobu
    Asakawa, Kyosuke
    Muraguchi, Taichi
    Muroyama, Yuko
    Shimokawa, Mariko
    Matsumura, Hiroyuki
    Nishimori, Yuriko
    Tan, Li Jing
    Hayano, Motoshi
    Sinclair, David A.
    Mohri, Yasuaki
    Nishimura, Emi K.
    [J]. DEVELOPMENTAL CELL, 2021, 56 (24) : 3309 - +
  • [4] Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
    Kim, Jeongkyu
    Sturgill, David
    Tran, Andy D.
    Sinclair, David A.
    Oberdoerffer, Philipp
    [J]. NUCLEIC ACIDS RESEARCH, 2016, 44 (07)
  • [5] Lopez-Otin C., 2023, HALLMARKS AGING EXPA
  • [6] Lu Y., 2020, NATURE, V186, P243, DOI [10.1016/j.cell.2022.11.001, DOI 10.1016/J.CELL.2022.11.001]
  • [7] Molecular pathology of rare progeroid diseases
    Rieckher, Matthias
    Garinis, George A.
    Schumacher, Bjorn
    [J]. TRENDS IN MOLECULAR MEDICINE, 2021, 27 (09) : 907 - 922
  • [8] Age-Dependent Ribosomal DNA Variations in Mice
    Watada, Eriko
    Li, Sihan
    Hori, Yutaro
    Fujiki, Katsunori
    Shirahige, Katsuhiko
    Inada, Toshifumi
    Kobayashi, Takehiko
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2020, 40 (22)
  • [9] Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
    White, Ryan R.
    Milholland, Brandon
    de Bruin, Alain
    Curran, Samuel
    Laberge, Remi-Martin
    van Steeg, Harry
    Campisi, Judith
    Maslov, Alexander Y.
    Vijg, Jan
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [10] Assessment of long-term impact of storm surges around the Korean Peninsula based on a large ensemble of climate projections
    Yang, Jung-A.
    Kim, Sooyoul
    Mori, Nobuhito
    Mase, Hajime
    [J]. COASTAL ENGINEERING, 2018, 142 : 1 - 8
1