SARS-CoV-2 spike antibody concentration in gamma globulin products from high-prevalence COVID-19 countries are transmitted to X-linked agammaglobulinemia patients

被引：3

作者：

Raphael, Allon ^{[1
]}

Shamriz, Oded ^{[2
,3
]}

Tvito, Ariella ^{[4
,5
]}

Magen, Sophie ^{[6
]}

Goldberg, Shmuel ^{[5
,7
]}

Megged, Orli ^{[5
,8
]}

Lev, Atar ^{[9
,10
,11
]}

Simon, Amos J. ^{[9
,10
]}

Tal, Yuval ^{[2
]}

Somech, Raz ^{[9
,10
,11
]}

Eisenberg, Rachel ^{[12
]}

Toker, Ori ^{[12
]}

机构：

[1] Shaare Zedek Med Ctr, Pediat Dept, Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Org, Dept Med,Allergy & Clin Immunol Unit, Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Inst Med Res Israel Canada, Fac Med, Lautenberg Ctr Immunol & Canc Res, Jerusalem, Israel

[4] Hebrew Univ Jerusalem, Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

[6] Shaare Zedek Med Ctr, Clin Endocrinol Lab, Jerusalem, Israel

[7] Hebrew Univ Jerusalem, Shaare Zedek Med Ctr, Dept Pediat, Pediat Pulmonol Unit, Jerusalem, Israel

[8] Hebrew Univ Jerusalem, Shaare Zedek Med Ctr, Dept Pediat, Infect Dis Unit, Jerusalem, Israel

[9] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Sackler Fac Med, Tel Hashomer Med Ctr,Pediat Dept A, Tel Aviv, Israel

[10] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Sackler Fac Med, Tel Hashomer Med Ctr,Immunol Serv, Tel Aviv, Israel

[11] Jeffrey Modell Fdn Israeli Network Primary Immunod, New York, NY USA

[12] Hebrew Univ Jerusalem, Fac Med, Shaare Zedek Med Ctr, Dept Pediat,Allergy & Clin Immunol Unit, Jerusalem, Israel

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

COVID-19; immunodeficiency; IVIg; antibodies; XLA; BRUTONS TYROSINE KINASE; PLECKSTRIN HOMOLOGY DOMAIN; MUTATION;

D O I：

10.3389/fimmu.2023.1156823

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PurposePatients with X-linked agammaglobulinemia (XLA) are characterized by humoral impairment and are routinely treated with intravenous immunoglobulin (IVIG). In this study, we aimed to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in IVIG preparations harvested globally and evaluate the transfer of SARS-CoV-2 antibodies to the XLA patient. MethodsA single-center, prospective cohort study was conducted in the period of November 2020 to November 2022. Clinical and laboratory data, specifically, SARS-CoV-2 spike IgG levels from the serum of 115 IVIG preparations given to 5 XLA patient were collected. Concurrently, SARS-CoV-2 spike IgG levels from the serum of the 5 XLA was collected monthly. ResultsFive XLA patients were evaluated within the study period. All were treated monthly with commercial IVIG preparations. A total of 115 IVIG treatments were given over the study period. The origin country and the date of IVIG harvesting was obtained for 111 (96%) of the treatments. Fifty-four IVIG preparations (49%) were harvested during the COVID-19 pandemic of which 76% were positive (>50AU/mL) for SARS-CoV-2 spike antibodies which were subsequently transmitted to the XLA patients in an approximate 10-fold reduction. SARS-CoV2 spike IgG was first detected in IVIG batches that completed their harvest date by September 2021. Positive products were harvested from origin countries with a documented prevalence over 2,000 per 100,000 population. ConclusionAs the prevalence of COVID-19 infections rises, detection of SARS-CoV-2 spike IgG in commercial IVIG products increases and is then transmitted to the patient. Future studies are needed to investigate the neutralizing capabilities of SARS-CoV-2 IgG and whether titer levels in IVIG remain consistent as the incidence of infection and vaccination rates in the population changes.

引用

页数：10

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