Low prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease in India

被引:4
作者
Singh, Arshdeep [1 ]
Midha, Vandana [2 ]
Narang, Vikram [3 ]
Kedia, Saurabh [4 ]
Mahajan, Ramit [1 ]
Dhoble, Pavan [5 ,6 ]
Kahlon, Bhavjeet Kaur [1 ]
Dhaliwal, Ashvin Singh [1 ]
Tripathi, Ashish [1 ]
Kalra, Shivam [1 ]
Jain, Narender Pal
Bansal, Namita [7 ]
Banerjee, Rupa [8 ]
Desai, Devendra [5 ,6 ]
Dutta, Usha [9 ]
Ahuja, Vineet
Sood, Ajit [1 ,10 ]
机构
[1] Dayanand Med Coll & Hosp, Dept Gastroenterol, Ludhiana, India
[2] Dayanand Med Coll & Hosp, Dept Internal Med, Ludhiana, India
[3] Dayanand Med Coll & Hosp, Dept Pathol, Ludhiana, India
[4] All India Inst Med Sci, Dept Gastroenterol, New Delhi, India
[5] P D Hinduja Natl Hosp, Mumbai, India
[6] Med Res Ctr, Mumbai, India
[7] Dayanand Med Coll & Hosp, Res & Dev Ctr, Dept Gastroenterol, Ludhiana, India
[8] Asian Inst Gastroenterol, Hyderabad, India
[9] Postgrad Inst Med Educ & Res, Dept Gastroenterol, Chandigarh, India
[10] Dayanand Med Coll & Hosp, Dept Gastroenterol, Ludhiana 141001, India
关键词
Colitis; ulcerative; Cholangitis; sclerosing; Prevalence; Inflammatory bowel diseases; India; ULCERATIVE-COLITIS; COLORECTAL-CANCER; EXTRAINTESTINAL MANIFESTATIONS; RISK; PHENOTYPE; IBD; HEPATOBILIARY; CHALLENGES; MANAGEMENT; DYSPLASIA;
D O I
10.5217/ir.2022.00087
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Primary sclerosing cholangitis (PSC) represents the most common hepatobiliary extraintestinal manifestation of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). Limited data exist on PSC in patients with IBD from India. We aimed to assess the prevalence and disease spectrum of PSC in Indian patients with IBD. Methods: Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively. Data were extracted and the prevalence of PSC-IBD was calculated. Results: Forty-eight patients out of 12,216 patients with IBD (9,231 UC, 2,939 CD, and 46 IBD unclassified) were identified to have PSC, resulting in a prevalence of 0.39%. The UC to CD ratio was 7:1. Male sex and pancolitis (UC) or colonic CD were more commonly associated with PSC-IBD. The diagnosis of IBD preceded the diagnosis of PSC in most of the patients. Majority of the patients were symptomatic for liver disease at diagnosis. Eight patients (16.66%) developed cirrhosis, 5 patients (10.41%), all UC, developed malignancies (3 colorectal cancer [6.25%] and 2 cholangiocarcinoma [4.16%]), and 3 patients died (2 decompensated liver disease [4.16%] and 1 cholangiocarcinoma [2.08%]) on follow-up. None of the patients mandated surgical therapy for IBD. Conclusions: Concomitant PSC in patients with IBD is uncommon in India and is associated with lower rates of development of malignancies. (Intest Res, Published online )
引用
收藏
页码:452 / 459
页数:8
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