Synthesis of biheteroaryls via 2-methyl quinoline C(sp3)-H functionalization under metal-free conditions

被引：6

作者：

Wang, Dahan ^{[1
,2
]}

Yang, Yuhan ^{[1
]}

Xiao, Fuhong ^{[1
]}

Liu, Jinbing ^{[2
]}

Mao, Guojiang ^{[3
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Hunan Prov Key Lab Green Organ Synth & Applicat, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

[2] Shaoyang Univ, Dept Food & Chem Engn, Shaoyang 422100, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2024年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

C(sp3)-H functionalization; Multicomponent reactions; Biheteroaryls; Elemental sulfur; Metal-free; ATOM ECONOMICAL APPROACH; ELEMENTAL SULFUR; ACCESS; STRAIGHTFORWARD; CONDENSATION; HETEROARENES;

D O I：

10.1016/j.gresc.2022.10.006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An acetic acid-promoted C(sp3)-H functionalization of 2-methyl quinoline, enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been developed. This approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group tolerance. Moreover, the success of the gram-scale reaction gives this reaction a great potential application.

引用

页码：73 / 76

页数：4

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