Dihydrophenanthrenes and phenanthrenes from Dendrobium terminale

被引：1

作者：

Cheng, Lei ^{[1
,2
,3
]}

Fang, Yi-Ke ^{[1
,2
]}

Zhang, Mao-Sheng ^{[1
,2
]}

Wang, Gang ^{[1
,2
]}

Dong, Min-Jian ^{[1
,2
]}

Sun, Cheng-Xin ^{[1
,2
]}

Xiao, Shi-Ji ^{[1
,2
,4
,5
,6
]}

机构：

[1] Zunyi Med Univ, Key Lab Basic Pharmacol Guizhou Prov, Zunyi, Guizhou, Peoples R China

[2] Zunyi Med Univ, Sch Pharm, Zunyi, Guizhou, Peoples R China

[3] First Peoples Hosp Bijie, Dept Pharm, Bijie, Peoples R China

[4] Guizhou Medcial Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China

[5] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi, Guizhou, Peoples R China

[6] Zunyi Med Univ, Joint Int Res Lab Ethnomed, Minist Educ, Zunyi, Guizhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 14期

关键词：

Dendrobium terminale; dihydrophenanthrene; phenanthrene; cytotoxicity; CONSTITUENTS; DERIVATIVES;

D O I：

10.1080/14786419.2022.2048379

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two previously undescribed dihydrophenanthrene derivatives (1 and 2) were isolated along with twelve known analogues from the whole plant of Dendrobium terminale. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. The NMR data of known phenanthrene derivatives (7 and 9) were revised by 2D NMR. The isolated compounds were evaluated for cytotoxicity against three kinds of tumor cell lines (sw1990, HCT-116, and HepG2). Especially compounds 11 and 14 showed stronger antitumor effects, and the structure-activity relationship of these compounds was discussed.

引用

页码：2375 / 2382

页数：8

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