Structural insights into ferroportin mediated iron transport

被引:2
|
作者
Jormakka, Mika [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Cell Biol, Kyoto, Japan
关键词
CHELATABLE IRON; HEPHAESTIN; HEPATOCYTES; EFFLUX; CERULOPLASMIN; MACROPHAGES; METABOLISM; MECHANISMS; EXPRESSION; PHENOTYPE;
D O I
10.1042/BST20230594
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Iron is a vital trace element for almost all organisms, and maintaining iron homeostasis is critical for human health. In mammals, the only known gatekeeper between intestinally absorbed iron and circulatory blood plasma is the membrane transporter ferroportin (Fpn). As such, dysfunction of Fpn or its regulation is a key driver of iron-related pathophysiology. This review focuses on discussing recent insights from high-resolution structural studies of the Fpn protein family. While these studies have unveiled crucial details of Fpn regulation and structural architecture, the associated functional studies have also at times provided conflicting data provoking more questions than answers. Here, we summarize key findings and illuminate important remaining questions and contradictions.
引用
收藏
页码:2143 / 2152
页数:10
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