Cobalt-Catalyzed Annulation of o-Phenylenediamines and Internal Alkynes: Efficient Synthesis of Quinoxaline Derivatives

被引：3

作者：

Zhao, Rui ^{[1
]}

Wu, Ling ^{[2
]}

Chen, Si-Wei ^{[1
]}

Cui, Zhen ^{[1
]}

Hu, Xu-Hua ^{[2
]}

Yang, Hui-Ru ^{[2
]}

Ye, Hongfei ^{[3
]}

Miao, Chun-Bao ^{[1
]}

Guo, Xun-Xiang ^{[2
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Minist Educ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Ophthalmol, Shanghai 200092, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 03期

关键词：

alkyne; cobalt; o-phenyldiamine; quinoxaline; synthetic methods; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; IODINE; FUNCTIONALIZATION; OXIDATION; INSIGHTS; DESIGN; ACCESS;

D O I：

10.1002/ejoc.202300919

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt-catalyzed annulation of o-phenylenediamines and internal alkynes for the synthesis of quinoxalines is developed. This method provides a variety of quinoxalines in good to high yields under a simple and mild reaction conditions with molecular O-2 as a terminal oxidant. Preliminary mechanistic studies show that a novel reaction mechanism is involved in the current reaction, which is different from the previous reported dicarbonyl compound mechanism via the oxidation of the alkyne.

引用

页数：6

共 54 条

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