Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults

被引：2
|
作者：
Slee, Michael G. [1 ]
Rainey-Smith, Stephanie R. [1 ,2 ,3 ,4 ]
Villemagne, Victor L. [5 ,6 ,7 ]
Doecke, James D. [8 ]
Sohrabi, Hamid R. [1 ,2 ,3 ,9 ]
Taddei, Kevin [2 ,3 ]
Ames, David [10 ,11 ,12 ]
Dore, Vincent [5 ]
Maruff, Paul [10 ,13 ]
Laws, Simon M. [7 ,14 ,15 ]
Masters, Colin L. [10 ]
Rowe, Christopher C. [5 ,10 ]
Martins, Ralph N. [2 ,3 ,9 ]
Erickson, Kirk I. [16 ]
Brown, Belinda M. [1 ,2 ,3 ]
机构：
[1] Murdoch Univ, Hlth Futures Inst, Ctr Hlth Ageing, Murdoch, WA, Australia
[2] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia
[3] Australian Alzheimers Res Fdn, Nedlands, WA, Australia
[4] Univ Western Australia, Sch Psychol Sci, Crawley, WA, Australia
[5] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia
[6] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
[7] Edith Cowan Univ, Ctr Precis Hlth, Joondalup, WA, Australia
[8] CSIRO, Australian E Hlth Res Ctr, Herston, Qld, Australia
[9] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia
[10] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia
[11] Natl Ageing Res Inst, Parkville, Vic, Australia
[12] Univ Melbourne, Acad Unit Psychiat Old Age, Carlton, Vic, Australia
[13] Cogstate Ltd, Melbourne, Vic, Australia
[14] Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Joondalup, WA, Australia
[15] Curtin Univ, Curtin Med Sch, Bentley, WA, Australia
[16] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA
来源：
ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 02期
基金：
英国医学研究理事会;
关键词：
Alzheimer's disease; amyloid beta; dementia; exercise; genetics; longitudinal; physical activity; ALZHEIMERS-DISEASE; LIFE-STYLE; MOUSE MODEL; EXERCISE; BIOMARKERS; NEURODEGENERATION; ACTIVATION; DECLINE; INSULIN; PLASMA;
D O I：
10.1002/alz.13556
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ss) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and A ss measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A ss. Moderation analyses examined apolipoprotein E (APOE) e4 carriage impact on the PA-A ss relationship. RESULTS: PA was not associated with brain A ss at baseline (ss = -0.001, p = 0.72) or over time (ss=-0.26, p= 0.24). APOE e4 status did not moderate the PA-A ss relationship over time (ss = 0.12, p = 0.73). Brain A ss levels did not predict PA trajectory (ss = -54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain A ss levels.
引用
收藏
页码：1350 / 1359
页数：10
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