Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults

被引：5

作者：

Slee, Michael G. ^{[1
]}

Rainey-Smith, Stephanie R. ^{[1
,2
,3
,4
]}

Villemagne, Victor L. ^{[5
,6
,7
]}

Doecke, James D. ^{[8
]}

Sohrabi, Hamid R. ^{[1
,2
,3
,9
]}

Taddei, Kevin ^{[2
,3
]}

Ames, David ^{[10
,11
,12
]}

Dore, Vincent ^{[5
]}

Maruff, Paul ^{[10
,13
]}

Laws, Simon M. ^{[7
,14
,15
]}

Masters, Colin L. ^{[10
]}

Rowe, Christopher C. ^{[5
,10
]}

Martins, Ralph N. ^{[2
,3
,9
]}

Erickson, Kirk I. ^{[16
]}

Brown, Belinda M. ^{[1
,2
,3
]}

机构：

[1] Murdoch Univ, Hlth Futures Inst, Ctr Hlth Ageing, Murdoch, WA, Australia

[2] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia

[3] Australian Alzheimers Res Fdn, Nedlands, WA, Australia

[4] Univ Western Australia, Sch Psychol Sci, Crawley, WA, Australia

[5] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia

[6] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[7] Edith Cowan Univ, Ctr Precis Hlth, Joondalup, WA, Australia

[8] CSIRO, Australian E Hlth Res Ctr, Herston, Qld, Australia

[9] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[10] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[11] Natl Ageing Res Inst, Parkville, Vic, Australia

[12] Univ Melbourne, Acad Unit Psychiat Old Age, Carlton, Vic, Australia

[13] Cogstate Ltd, Melbourne, Vic, Australia

[14] Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Joondalup, WA, Australia

[15] Curtin Univ, Curtin Med Sch, Bentley, WA, Australia

[16] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 02期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; amyloid beta; dementia; exercise; genetics; longitudinal; physical activity; ALZHEIMERS-DISEASE; LIFE-STYLE; MOUSE MODEL; EXERCISE; BIOMARKERS; NEURODEGENERATION; ACTIVATION; DECLINE; INSULIN; PLASMA;

D O I：

10.1002/alz.13556

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ss) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and A ss measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A ss. Moderation analyses examined apolipoprotein E (APOE) e4 carriage impact on the PA-A ss relationship. RESULTS: PA was not associated with brain A ss at baseline (ss = -0.001, p = 0.72) or over time (ss=-0.26, p= 0.24). APOE e4 status did not moderate the PA-A ss relationship over time (ss = 0.12, p = 0.73). Brain A ss levels did not predict PA trajectory (ss = -54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain A ss levels.

引用

页码：1350 / 1359

页数：10

共 52 条

[11] Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review [J].

Brown, Belinda M. ;

Peiffer, Jeremiah ;

Rainey-Smith, Stephanie R. .

AGEING RESEARCH REVIEWS, 2019, 50 :9-18

[12] Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography [J].

Brown, Belinda M. ;

Rainey-Smith, Stephanie R. ;

Dore, Vincent ;

Peiffer, Jeremiah J. ;

Burnham, Samantha C. ;

Laws, Simon M. ;

Taddei, Kevin ;

Ames, David ;

Masters, Colin L. ;

Rowe, Christopher C. ;

Martins, Ralph N. ;

Villemagne, Victor L. .

JOURNAL OF ALZHEIMERS DISEASE, 2018, 63 (04) :1299-1305

[13] Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom [J].

Cleland, Claire ;

Ferguson, Sara ;

Ellis, Geraint ;

Hunter, Ruth F. .

BMC MEDICAL RESEARCH METHODOLOGY, 2018, 18

[14] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[15] Exercise enhances and protects brain function [J].

Cotman, CW ;

Engesser-Cesar, C .

EXERCISE AND SPORT SCIENCES REVIEWS, 2002, 30 (02) :75-79

[16] Insulin and Alzheimer's Disease: Untangling the Web [J].

Craft, Suzanne ;

Cholerton, Brenna ;

Baker, Laura D. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 :S263-S275

[17] International physical activity questionnaire:: 12-country reliability and validity [J].

Craig, CL ;

Marshall, AL ;

Sjöström, M ;

Bauman, AE ;

Booth, ML ;

Ainsworth, BE ;

Pratt, M ;

Ekelund, U ;

Yngve, A ;

Sallis, JF ;

Oja, P .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2003, 35 (08) :1381-1395

[18] Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review [J].

de Frutos-Lucas, Jaisalmer ;

Frost, Natalie ;

Erickson, Kirk I. ;

Serrano, Juan M. ;

Maestu, Fernando ;

Laws, Simon M. ;

Brown, Belinda M. .

AGEING RESEARCH REVIEWS, 2020, 64

[19] Physical Activity and Brain Health [J].

Di Liegro, Carlo Maria ;

Schiera, Gabriella ;

Proia, Patrizia ;

Di Liegro, Italia .

GENES, 2019, 10 (09)

[20] Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology [J].

Dore, Vincent ;

Bullich, Santiago ;

Rowe, Christopher C. ;

Bourgeat, Pierrick ;

Konate, Salamata ;

Sabri, Osama ;

Stephens, Andrew W. ;

Barthel, Henryk ;

Fripp, Jurgen ;

Masters, Colin L. ;

Dinkelborg, Ludger ;

Salvado, Olivier ;

Villemagne, Victor L. ;

De Santi, Susan .

ALZHEIMERS & DEMENTIA, 2019, 15 (06) :807-816

← 1 2 3 4 5 6 →