Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults

被引：5

作者：

Slee, Michael G. ^{[1
]}

Rainey-Smith, Stephanie R. ^{[1
,2
,3
,4
]}

Villemagne, Victor L. ^{[5
,6
,7
]}

Doecke, James D. ^{[8
]}

Sohrabi, Hamid R. ^{[1
,2
,3
,9
]}

Taddei, Kevin ^{[2
,3
]}

Ames, David ^{[10
,11
,12
]}

Dore, Vincent ^{[5
]}

Maruff, Paul ^{[10
,13
]}

Laws, Simon M. ^{[7
,14
,15
]}

Masters, Colin L. ^{[10
]}

Rowe, Christopher C. ^{[5
,10
]}

Martins, Ralph N. ^{[2
,3
,9
]}

Erickson, Kirk I. ^{[16
]}

Brown, Belinda M. ^{[1
,2
,3
]}

机构：

[1] Murdoch Univ, Hlth Futures Inst, Ctr Hlth Ageing, Murdoch, WA, Australia

[2] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia

[3] Australian Alzheimers Res Fdn, Nedlands, WA, Australia

[4] Univ Western Australia, Sch Psychol Sci, Crawley, WA, Australia

[5] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia

[6] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[7] Edith Cowan Univ, Ctr Precis Hlth, Joondalup, WA, Australia

[8] CSIRO, Australian E Hlth Res Ctr, Herston, Qld, Australia

[9] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[10] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[11] Natl Ageing Res Inst, Parkville, Vic, Australia

[12] Univ Melbourne, Acad Unit Psychiat Old Age, Carlton, Vic, Australia

[13] Cogstate Ltd, Melbourne, Vic, Australia

[14] Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Joondalup, WA, Australia

[15] Curtin Univ, Curtin Med Sch, Bentley, WA, Australia

[16] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 02期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; amyloid beta; dementia; exercise; genetics; longitudinal; physical activity; ALZHEIMERS-DISEASE; LIFE-STYLE; MOUSE MODEL; EXERCISE; BIOMARKERS; NEURODEGENERATION; ACTIVATION; DECLINE; INSULIN; PLASMA;

D O I：

10.1002/alz.13556

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ss) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and A ss measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A ss. Moderation analyses examined apolipoprotein E (APOE) e4 carriage impact on the PA-A ss relationship. RESULTS: PA was not associated with brain A ss at baseline (ss = -0.001, p = 0.72) or over time (ss=-0.26, p= 0.24). APOE e4 status did not moderate the PA-A ss relationship over time (ss = 0.12, p = 0.73). Brain A ss levels did not predict PA trajectory (ss = -54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain A ss levels.

引用

页码：1350 / 1359

页数：10

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