Indole-3-acetic acid impacts biofilm formation and virulence production of Pseudomonas aeruginosa

被引：8

作者：

Jayaraman, Sudharshini ^{[1
]}

Kannan, Monika Adhilaxmi ^{[1
]}

Rajendhran, Nandhini ^{[1
]}

John, Georrge J. ^{[2
]}

Ramasamy, Thirumurugan ^{[1
]}

机构：

[1] Bharathidasan Univ, Sch Life Sci, Dept Anim Sci, Lab Aquabiot Nanosci, Tiruchirappalli, Tamil Nadu, India

[2] Univ North Bengal, Dept Bioinformat, Raja Rammohunpur, W Bengal, India

来源：

BIOFOULING | 2023年 / 39卷 / 08期

关键词：

Antibacterial compounds; antimicrobial resistance; bacterial biofilm; pathogenesis; virulence factors; INDOLE; PROTEIN; ACID; NANOPARTICLES; INHIBITION; MOLECULE; GROWTH; AUXINS;

D O I：

10.1080/08927014.2023.2269537

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial pathogenesis involves complex mechanisms contributing to virulence and persistence of infections. Understanding the multifactorial nature of bacterial infections is crucial for developing effective interventions. The present study investigated the efficacy of indole-3-acetic acid (IAA) against Pseudomonas aeruginosa with various end points including antibacterial activity, minimum inhibitory concentration (MIC), virulence factor production, biofilm inhibition, bacterial cell detachment, and viability assays. Results showed significant biofilm inhibition, bacterial cell detachment, and modest effects on bacterial viability. Microscopic analysis confirmed the disintegrated biofilm matrix, supporting the inhibitory effect of IAA. Additionally, molecular docking studies revealed potential mechanisms of action through active bond interactions between IAA and virulence proteins. These findings highlight IAA as an effective antibiofilm agent against P. aeruginosa.

引用

页码：800 / 815

页数：16

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