Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist

被引：4

作者：

Huang, Sophia ^{[1
]}

de Jong, Dorine ^{[2
]}

Das, Jeeban P. ^{[3
]}

Widemon, Reginald Scott ^{[1
]}

Braumuller, Brian ^{[1
]}

Paily, Jacienta ^{[1
]}

Deng, Aileen ^{[4
]}

Liou, Connie ^{[1
]}

Roa, Tina ^{[1
]}

Huang, Alice ^{[1
]}

Ma, Hong

D'Souza, Belinda ^{[1
]}

Leb, Jay ^{[1
]}

L'Hereaux, Jade ^{[1
]}

Nguyen, Pamela ^{[1
]}

Luk, Lyndon ^{[1
]}

Francescone, Mark ^{[1
]}

Yeh, Randy ^{[3
]}

Maccarrone, Valerie ^{[1
]}

Dercle, Laurent ^{[1
]}

Salvatore, Mary M. ^{[1
]}

Capaccione, Kathleen M. ^{[1
,5
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Dept Radiol, 622 W 168th St, New York, NY 10032 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Immunol, 1275 York Ave, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10065 USA

[4] Novant Hlth, Dept Hematol & Oncol, 170 Med Pk Rd, Mooresville, NC 28117 USA

[5] Columbia Univ, Irving Med Ctr, Dept Radiol, 622 W 168th St,PH 301, New York, NY 10032 USA

来源：

ACADEMIC RADIOLOGY | 2023年 / 30卷 / 11期

关键词：

CAR T cell therapy; immunology; adverse events; imaging; ACUTE KIDNEY INJURY; PULMONARY TOXICITIES; MANAGEMENT; NEUROTOXICITY; IMMUNOTHERAPY; DIAGNOSIS; LYMPHOMA; EVENTS; ADULTS;

D O I：

10.1016/j.acra.2023.04.004

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.

引用

页码：2712 / 2727

页数：16

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