Exploiting ion-mobility mass spectrometry for unraveling proteome complexity

被引：1

作者：

Perchepied, Stan ^{[1
]}

Zhou, Zhuoheng ^{[1
]}

Mitulovic, Goran ^{[2
]}

Eeltink, Sebastiaan ^{[1
,3
]}

机构：

[1] Vrije Univ Brussel VUB, Dept Chem Engn, Brussels, Belgium

[2] Bruker Daltonics Inc, Vienna, Austria

[3] Pl Laan 2, B-1050 Brussels, Belgium

来源：

JOURNAL OF SEPARATION SCIENCE | 2023年 / 46卷 / 18期

关键词：

clinical proteomics; data-independent acquisition; parallel accumulation-serial fragmentation; single-cell analysis; TIMS-TOF; IDENTIFICATION; FUNDAMENTALS; SEPARATION; ELECTROPHORESIS; SENSITIVITY; RESOLUTION; PROTEINS; SEQUENCE; GLYCAN; POWER;

D O I：

10.1002/jssc.202300512

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ion mobility spectrometry-mass spectrometry (IMS-MS) is experiencing rapid growth in proteomic studies, driven by its enhancements in dynamic range and throughput, increasing the quantitation precision, and the depth of proteome coverage. The core principle of ion mobility spectrometry is to separate ions in an inert gas under the influence of an electric field based on differences in drift time. This minireview provides an introduction to IMS operation modes and a description of advantages and limitations is presented. Moreover, the principles of trapped IMS-MS (TIMS-MS), including parallel accumulation-serial fragmentation are discussed. Finally, emerging applications linked to TIMS focusing on sample throughput (in clinical proteomics) and sensitivity (single-cell proteomics) are reviewed, and the possibilities of intact protein analysis are discussed.

引用

页数：16

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