Nutraceuticals a Food for Thought in the Treatment of Parkinson's Disease

被引:4
作者
Bansal, Keshav [1 ]
Singh, Sakshi [1 ]
Singh, Vanshita [1 ]
Bajpai, Meenakshi [1 ]
机构
[1] GLA Univ, Inst Pharmaceut Res, Mathura, India
关键词
Nutraceuticals; Parkinson's disease; oxidative stress; mitochondrial dysfunction; nutritional food; PD symptoms; CEREBRAL ISCHEMIA-REPERFUSION; ALPHA-SYNUCLEIN; GALLIC ACID; ASIATIC ACID; MOUSE MODEL; RAT MODEL; PHARMACOLOGICAL-ACTIVITIES; INDUCED NEUROTOXICITY; OXIDATIVE STRESS; ROSMARINIC ACID;
D O I
10.2174/1573401319666230515104325
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background Brain disorders are presently one of the most serious and challenging health issues in the world. A significant portion of morbidities and fatalities worldwide are caused by these brain disorders. Parkinson's disease (PD) is a neurological condition that develops when dopaminergic neurons are lost in the substantia nigra, causing cognitive and motor impairment.Objectives Conventional treatment modalities, including dopamine replacement therapy and optimization of dopaminergic transmission approaches, don't address the pathogenic processes primary to the symptoms of PD and usually become the least essential with time. Researchers are aiming to provide effective treatment in treating PD with minimizing adverse consequences. In the past few years, a number of studies on nutraceuticals have been conducted to produce foods with fewer adverse effects and increased therapeutic effectiveness. The use of these nutraceuticals is typically risk-free and can be coupled with the patient's current common pharmacological therapy to enhance the standard of living and lessen PD symptoms.Conclusion The current review focuses on a number of important nutritional compounds and dietary changes that have been shown to be effective against a number of the pathogenic pathways involved in the onset and progression of Parkinson's disease (PD), and further lights the justification for their prospect use in the treatment and prevention of PD.
引用
收藏
页码:961 / 977
页数:17
相关论文
共 173 条
  • [11] Carnisone increases efficiency of DOPA therapy of Parkinson's disease: A pilot study
    Boldyrev, Alexander
    Fedorova, Tatiana
    Stepanova, Maria
    Dobrotvorskaya, Irina
    Kozlova, Eugenia
    Boldanova, Natalia
    Bagyeva, Gulbakhar
    Ivanova-Smolenskaya, Irina
    Illarioshkin, Serguey
    [J]. REJUVENATION RESEARCH, 2008, 11 (04) : 821 - 827
  • [12] Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
    Cai, Guoen
    Lin, Fabin
    Wu, Dihang
    Lin, Chenxin
    Chen, Huiyun
    Wei, Yicong
    Weng, Huidan
    Chen, Zhiting
    Wu, Minxia
    Huang, En
    Ye, Zucheng
    Ye, Qinyong
    [J]. FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [13] Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease
    Carrera, Ivan
    Cacabelos, Ramon
    [J]. CURRENT NEUROPHARMACOLOGY, 2019, 17 (03) : 295 - 306
  • [14] Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line
    Chandrasekhar, Y.
    Kumar, G. Phani
    Ramya, E. M.
    Anilakumar, K. R.
    [J]. NEUROCHEMICAL RESEARCH, 2018, 43 (06) : 1150 - 1160
  • [15] Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease
    Chao, Jianfei
    Leung, Yen
    Wang, Mingfu
    Chang, Raymond Chuen-Chung
    [J]. NUTRITION REVIEWS, 2012, 70 (07) : 373 - 386
  • [16] Chao PC, 2016, FOOD FUNCT, V7, P1999, DOI [10.1039/c6fo00041j, 10.1039/C6FO00041J]
  • [17] Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production
    Chen, Dong
    Zhang, Xiao-Ya
    Sun, Jing
    Cong, Qi-Jie
    Chen, Wei-Xiong
    Ahsan, Hafiz Muhammad
    Gao, Jing
    Qian, Jin-Jun
    [J]. BIOMOLECULES & THERAPEUTICS, 2019, 27 (05) : 442 - 449
  • [18] A review for the pharmacological effect of lycopene in central nervous system disorders
    Chen, Dongjian
    Huang, Chao
    Chen, Zhuo
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2019, 111 : 791 - 801
  • [19] Clinical Progression in Parkinson Disease and the Neurobiology of Axons
    Cheng, Hsiao-Chun
    Ulane, Christina M.
    Burke, Robert E.
    [J]. ANNALS OF NEUROLOGY, 2010, 67 (06) : 715 - 725
  • [20] Discovery of ubiquinone (coenzyme Q) and an overview of function
    Crane, Frederick L.
    [J]. MITOCHONDRION, 2007, 7 : S2 - S7