Multicomponent Radical Cross-Coupling Reaction of [1.1.1]Propellane: Synthesis of 1-Arylthiol-3-Heteroaryl Bicyclo[1.1.1]pentanes &DAG;

被引：6

作者：

Li, Lin ^{[1
]}

Liu, Yumiao ^{[1
]}

Li, Jian ^{[1
]}

Chen, Qing ^{[1
]}

Zhang, Pengfei ^{[1
]}

Shen, Jiabin ^{[1
,2
]}

Wu, Jirong ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Key Lab Organosilicon Mat Technol,Minist Educ, Hangzhou 311121, Peoples R China

[2] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Hangzhou 310015, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Bicyclo[1; 1; 1]pentane; Visible light; Photocatalyst-free; C-H Functionalization; Multi-bond formation; ARYL ACYL PEROXIDES; METAL; QUINOXALIN-2(1H)-ONES; ROUTE; ARYLATION;

D O I：

10.1002/adsc.202300534

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, a visible light-mediated multicomponent radical cross-coupling reaction of [1.1.1]propellane with N-heterocycles and disulfides is described. The mild conditions enabled the installation of the BCP motif in a wide variety of compounds in the absence of photocatalyst, additive and metal catalyst, with excellent functional group tolerance, This methodology opens a approach for the synthesis of potentially bioactive 1-arylthiol-3-heteroaryl bicyclo[1.1.1]pentanes in moderate to good yield.

引用

页码：3112 / 3117

页数：6

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