Novel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment

被引：39

作者：

Rashid, Zainab Ahmed ^{[1
]}

Bardaweel, Sanaa K. ^{[1
]}

机构：

[1] Univ Jordan, Sch Pharm, Dept Pharmaceut Sci, Amman 11942, Jordan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期

关键词：

MMP-9; matrix metalloproteinase; inhibitors; molecular docking; anticancer; MATRIX-METALLOPROTEINASE INHIBITOR; CLINICAL-TRIALS GROUP; AIDED DRUG DESIGN; PHASE-I TRIAL; GELATINASE-B; HYDROXAMATE INHIBITORS; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; ORTHOTOPIC MODEL; BATIMASTAT BB-94;

D O I：

10.3390/ijms241512133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent proteolytic metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the most intricate MMPs. The crucial involvement of MMP-9 in extracellular matrix (ECM) remodeling underscores its significant correlation with each stage of cancer pathogenesis and progression. The design and synthesis of MMP-9 inhibitors is a potentially attractive research area. Unfortunately, to date, there is no effective MMP-9 inhibitor that passes the clinical trials and is approved by the FDA. This review primarily focuses on exploring the diverse strategies employed in the design and advancement of MMP-9 inhibitors, along with their anticancer effects and selectivity. To illuminate the essential structural characteristics necessary for the future design of novel MMP-9 inhibitors, the current narrative review highlights several recently discovered MMP-9 inhibitors exhibiting notable selectivity and potency.

引用

页数：24

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