Recent advances in regulating lipid metabolism to prevent coronary heart disease

被引：9
作者：
Du, Jingchun [1 ,2 ]
Wu, Wei [3 ]
Zhu, Boran [1 ,2 ]
Tao, Weiwei [1 ,2 ]
Liu, Lina [1 ,2 ]
Cheng, Xiaolan [1 ,2 ]
Zhao, Min [1 ,2 ]
Wu, Jibiao [4 ]
Li, Yunlun [5 ]
Pei, Ke [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Sch Tradit Chinese Med, Nanjing 210023, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Integrated Chinese & Western Med, Nanjing 210023, Peoples R China
[3] Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing 210023, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250355, Peoples R China
[5] Shandong Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Jinan 250355, Peoples R China
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2023年 / 255卷
关键词：
Coronary heart disease; Atherosclerosis; Lipid metabolism; Influencing factors; Preventive treatment; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; HIGH-RISK; CERAMIDES; OBESITY; CELLS; ACID; CHOLESTEROL; THERAPIES; HEALTH;
D O I：
10.1016/j.chemphyslip.2023.105325
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pathogenesis of coronary heart disease is a highly complex process, with lipid metabolism disorders being closely linked to its development. Therefore, this paper analyzes the various factors that influence lipid metabolism, including obesity, genes, intestinal microflora, and ferroptosis, through a comprehensive review of basic and clinical studies. Additionally, this paper delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, it proposes various intervention pathways and therapeutic methods, such as the regulation of lipoprotein enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease.
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页数：14
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