Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells

被引：8

作者：

Awad, Wael ^{[1
,2
]}

Ciacchi, Lisa ^{[1
,2
]}

McCluskey, James ^{[3
]}

Fairlie, David P. ^{[4
]}

Rossjohn, Jamie ^{[1
,2
,5
]}

机构：

[1] Monash Univ, Infect & Immun Program, Clayton, Vic 3800, Australia

[2] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[3] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia

[4] Univ Queensland, Inst Mol Biosci, ARC Ctr Excellence Innovat Peptide & Prot Sci, Brisbane, Qld 4072, Australia

[5] Cardiff Univ, Inst Infect & Immun, Sch Med, Heath Pk, Cardiff CF14 4XN, Wales

来源：

CURRENT OPINION IN IMMUNOLOGY | 2023年 / 83卷

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

RECEPTOR HETEROGENEITY; ACTIVATION; PATHWAY;

D O I：

10.1016/j.coi.2023.102351

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Metabolite-based T-cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, and cancer. Here, small-molecule metabolites were identified to be captured and presented by the major histocompatibility complex class-I-related molecule (MR1) to T cells, namely mucosal-associated invariant T cells (MAIT) and diverse MR1-restricted T cells. Both MR1 and MAIT are evolutionarily conserved in many mammals, suggesting important roles in host immunity. Rational chemical modifications of these naturally occurring metabolites, termed altered metabolite ligands (AMLs), have advanced our understanding of the molecular correlates of MAIT T cell receptor (TCR)-MR1 recognition. This review provides a generalized framework for metabolite recognition and modulation of MAIT cells.

引用

页数：8

共 45 条

[1] The molecular basis underpinning the potency and specificity of MAIT cell antigens
Awad, Wael
Ler, Geraldine J. M.
Xu, Weijun
Keller, Andrew N.
Mak, Jeffrey Y. W.
Lim, Xin Yi
Liu, Ligong
Eckle, Sidonia B. G.
Le Nours, Jerome
McCluskey, James
Corbett, Alexandra J.
Fairlie, David P.
Rossjohn, Jamie
[J]. NATURE IMMUNOLOGY, 2020, 21 (04) : 400 - +
[2] Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1
Awad, Wael
Le Nours, Jerome
Kjer-Nielsen, Lars
McCluskey, James
Rossjohn, Jamie
[J]. IMMUNOLOGY AND CELL BIOLOGY, 2018, 96 (06) : 588 - 597
[3] Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands
Braganza, Chriselle D.
Motozono, Chihiro
Sonoda, Koh-Hei
Yamasaki, Sho
Shibata, Kensuke
Timmer, Mattie S. M.
Stocker, Bridget L.
[J]. CHEMICAL COMMUNICATIONS, 2020, 56 (39) : 5291 - 5294
[4] The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation
Braganza, Chriselle D.
Shibata, Kensuke
Fujiwara, Aisa
Motozono, Chihiro
Sonoda, Koh-Hei
Yamasaki, Sho
Stocker, Bridget L.
Timmer, Mattie S. M.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 17 (40) : 8992 - 9000
[5] MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Constantinides, Michael G.
Link, Verena M.
Tamoutounour, Samira
Wong, Andrea C.
Perez-Chaparro, P. Juliana
Han, Seong-Ji
Chen, Y. Erin
Li, Kelin
Farhat, Sepideh
Weckel, Antonin
Krishnamurthy, Siddharth R.
Vujkovic-Cvijin, Ivan
Linehan, Jonathan L.
Bouladoux, Nicolas
Merrill, E. Dean
Roy, Sobhan
Cua, Daniel J.
Adams, Erin J.
Bhandoola, Avinash
Scharschmidt, Tiffany C.
Aube, Jeffrey
Fischbach, Michael A.
Belkaid, Yasmine
[J]. SCIENCE, 2019, 366 (6464) : 445 - +
[6] T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Corbett, Alexandra J.
Eckle, Sidonia B. G.
Birkinshaw, Richard W.
Liu, Ligong
Patel, Onisha
Mahony, Jennifer
Chen, Zhenjun
Reantragoon, Rangsima
Meehan, Bronwyn
Cao, Hanwei
Williamson, Nicholas A.
Strugnell, Richard A.
Van Sinderen, Douwe
Mak, Jeffrey Y. W.
Fairlie, David P.
Kjer-Nielsen, Lars
Rossjohn, Jamie
McCluskey, James
[J]. NATURE, 2014, 509 (7500) : 361 - +
[7] Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Crowther, Michael D.
Dotlon, Garry
Legut, Mateusz
Caillaud, Marine E.
Lloyd, Angharad
Attaf, Meriem
Galloway, Sarah A. E.
Rius, Cristina
Farrell, Colin P.
Szomolay, Barbara
Ager, Ann
Parker, Alan L.
Fuller, Anna
Donia, Marco
McCluskey, James
Rossjohn, Jamie
Svane, Inge Marie
Phillips, John D.
Sewell, Andrew K.
[J]. NATURE IMMUNOLOGY, 2020, 21 (02) : 178 - +
[8] Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
Eckle, Sidonia B. G.
Corbett, Alexandra J.
Keller, Andrew N.
Chen, Zhenjun
Godfrey, Dale I.
Liu, Ligong
Mak, Jeffrey Y. W.
Fairlie, David P.
Rossjohn, Jamie
McCluskey, James
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (51) : 30204 - 30211
[9] A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells
Eckle, Sidonia B. G.
Birkinshaw, Richard W.
Kostenko, Lyudmila
Corbett, Alexandra J.
McWilliam, Hamish E. G.
Reantragoon, Rangsima
Chen, Zhenjun
Gherardin, Nicholas A.
Beddoe, Travis
Liu, Ligong
Patel, Onisha
Meehan, Bronwyn
Fairlie, David P.
Villadangos, Jose A.
Godfrey, Dale I.
Kjer-Nielsen, Lars
McCluskey, James
Rossjohn, Jamie
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (08) : 1585 - 1600
[10] Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition
Gherardin, Nicholas A.
Keller, Andrew N.
Woolley, Rachel E.
Le Nours, Jerome
Ritchie, David S.
Neeson, Paul J.
Birkinshaw, Richard W.
Eckle, Sidonia B. G.
Waddington, John N.
Liu, Ligong
Fairlie, David P.
Uldrich, Adam P.
Pellicci, Daniel G.
McCluskey, James
Godfrey, Dale I.
Rossjohn, Jamie
[J]. IMMUNITY, 2016, 44 (01) : 32 - 45

← 1 2 3 4 5 →