The role of transforming growth factor beta in bicuspid aortic valve aortopathy

被引：2
作者：
Grewal, Nimrat [1 ,2 ,3 ]
Dolmaci, Onur [1 ,2 ]
Klautz, Arthur [1 ,2 ]
Legue, Juno [1 ]
Driessen, Antoine [1 ]
Klautz, Robert [1 ,2 ]
Poelmann, Robert [4 ,5 ]
机构：
[1] Univ Amsterdam, Dept Cardiothorac Surg, Med Ctr, Amsterdam, Netherlands
[2] Leiden Univ, Dept Cardiothorac Surg, Med Ctr, Leiden, Netherlands
[3] Leiden Univ, Dept Anat & Embryol, Med Ctr, Leiden, Netherlands
[4] Leiden Univ, Inst Biol Anim Sci & Hlth, Leiden, Netherlands
[5] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
来源：
INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 2023年 / 39卷 / SUPPL 2期
关键词：
Bicuspid aortic valve; TGF-beta; Thoracic aortopathy; Molecular biology; Embryology; SMOOTH-MUSCLE-CELLS; MARFAN-SYNDROME; ANEURYSM; DIFFERENTIATION; COMPLICATIONS; WALL; HEMODYNAMICS; PATHOGENESIS; ASSOCIATION; DILATATION;
D O I：
10.1007/s12055-023-01513-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-ss) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.
引用
收藏
页码：270 / 279
页数：10
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