Combined Effect of Omega-3 Fatty Acid and Vitamin D3 on Oxidized LDL-C and Non-HDL-C Levels in People With Vitamin D Deficiency: A Randomized Controlled Trial

被引:4
作者
Mehdawi, Amani [1 ]
Mohammad, Beisan A. [2 ]
Mosleh, Ibrahim [3 ]
Khader, Heba A. [4 ]
Habash, Maha [5 ]
Nassar, Razan I. [1 ]
Awwad, Shady [6 ]
Hasoun, Luai [1 ]
Abu-Samak, Mahmoud S. [1 ,7 ]
机构
[1] Appl Sci Private Univ, Fac Pharm, Dept Clin Pharm & Therapeut, Amman, Jordan
[2] Fakeeh Coll Med Sci, Dept Pharmaceut Sci, Jeddah, Saudi Arabia
[3] Univ Jordan, Dept Med Lab Sci, Amman, Jordan
[4] Hashemite Univ, Fac Pharmaceut Sci, Dept Clin Pharm & Pharm Practice, Zarqa, Jordan
[5] Aqaba Univ Technol, Michael Sayegh Fac Pharm, Aqaba, Jordan
[6] Appl Sci Private Univ, Fac Pharm, Dept Pharmaceut Chem & Pharmacognosy, Amman, Jordan
[7] Appl Sci Private Univ, Fac Pharm, Dept Clin Pharm & Therapeut, Jordan Al Arab St 21, Amman 11931, Jordan
关键词
vitamin D deficiency; vitamin D-3; omega-3 fatty acids; non-HDL; oxidized-LDL cholesterol; LDL-C; TG; CARDIOVASCULAR-DISEASE; D SUPPLEMENTATION; LIPID PROFILE; METABOLIC SYNDROME; CARDIOMETABOLIC RISK; GLYCEMIC CONTROL; FATTY-ACIDS; METAANALYSIS; CHOLESTEROL; RECEPTOR;
D O I
10.1097/FJC.0000000000001398
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present randomized clinical trial (RCT) was conducted on Jordanian participants with vitamin D deficiency (VDD) with no other medical conditions, to evaluate the combined effect of 1,25-dihydroxy vitamin D-3 (Vit.D-3) and omega-3 fatty acid (n-3FA) supplements (D+) on oxidized low-density lipoprotein (Ox-LDL) and non-high-density lipoprotein cholesterol (non-HDL-C) levels as common predictors of cardiovascular diseases (CVDs). Participants were randomized into 4 groups as follows: a control group (C) that received no supplementations, a Vit.D-3 group that received 50,000 IU of Vit.D-3 every week, an n-3FA group that received 300 mg of omega-3 fatty acid every day, and a D+ group that received a combination of both supplements, with the same dosage administered by the previous groups but with a 4-6-hour time interval between Vit.D-3 and n-3FA administration to avoid any possible interaction. All supplementations were administered orally for 8 weeks. Forty-seven participants were allocated to each group. Twenty-six in the control group, 37 participants in the Vit.D-3 group, 37 participants in the n-3FA group, and 46 participants in the D+ group completed the study to the end. The D+ supplementations significantly increased non-HDL-C (118.99 +/- 60.98 to 155.26 +/- 43.36 mg/dL, P << 0.05) but decreased Ox-LDL-C levels (69.29 +/- 37.69 to 52.81 +/- 17.30 pg/mL, P = 0.03). The stepwise regression showed that the serum LDL-C level was the main independent variable involved in the elevation of non-HDL levels (R-2 = 0.837) observed at the end of the trial in the D+ group. The groups that were supplemented with either Vit.D-3 alone or n-3FA alone had an insignificant decrease in the level of Ox-LDL-C. In conclusion, despite the observed hyperlipidemic effect, the combination treatment is recommended by the research team because the decrease in Ox-LDL may offset the hyperlipidemic effect.
引用
收藏
页码:251 / 258
页数:8
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