Self-Assembled Nanodelivery System with Rapamycin and Curcumin for Combined Photo-Chemotherapy of Breast Cancer

被引：8

作者：

Yin, Yanlong ^{[1
]}

Jiang, Hong ^{[1
]}

Wang, Yue ^{[1
]}

Zhang, Longyao ^{[1
]}

Sun, Chunyan ^{[2
]}

Xie, Pan ^{[2
]}

Zheng, Kun ^{[2
]}

Wang, Shaoqing ^{[1
]}

Yang, Qian ^{[1
]}

机构：

[1] Chengdu Med Coll, Affiliated Hosp 2, China Natl Nucl Corp Hosp 416, Ctr Sci Res, Chengdu 610500, Peoples R China

[2] Chengdu Med Coll, Sch Biosci & Technol, 783,Xindu Ave, Chengdu 610500, Peoples R China

来源：

PHARMACEUTICS | 2023年 / 15卷 / 03期

关键词：

nanodelivery system; rapamycin; curcumin; chemo-phototherapy; breast cancer; RESPONSIVE NANOPARTICLES; INDOCYANINE GREEN; MAMMALIAN TARGET; TRASTUZUMAB; DELIVERY; THERAPY; FLUORESCENCE; STRATEGIES; AGENT; DRUGS;

D O I：

10.3390/pharmaceutics15030849

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanodelivery systems combining photothermal therapy (PTT) and chemotherapy (CT), have been widely used to improve the efficacy and biosafety of chemotherapeutic agents in cancer. In this work, we constructed a self-assembled nanodelivery system, formed by the assembling of photosensitizer (IR820), rapamycin (RAPA), and curcumin (CUR) into IR820-RAPA/CUR NPs, to realize photothermal therapy and chemotherapy for breast cancer. The IR820-RAPA/CUR NPs displayed a regular sphere, with a narrow particle size distribution, a high drug loading capacity, and good stability and pH response. Compared with free RAPA or free CUR, the nanoparticles showed a superior inhibitory effect on 4T1 cells in vitro. The IR820-RAPA/CUR NP treatment displayed an enhanced inhibitory effect on tumor growth in 4T1 tumor-bearing mice, compared to free drugs in vivo. In addition, PTT could provide mild hyperthermia (46.0 degrees C) for 4T1 tumor-bearing mice, and basically achieve tumor ablation, which is beneficial to improving the efficacy of chemotherapeutic drugs and avoiding damage to the surrounding normal tissue. The self-assembled nanodelivery system provides a promising strategy for coordinating photothermal therapy and chemotherapy to treat breast cancer.

引用

页数：15

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