Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

被引：45
作者：
Guan, Guangzhao [1 ,2 ]
Cannon, Richard D. D. [1 ,3 ]
Coates, Dawn E. E. [1 ]
Mei, Li [1 ,3 ]
机构：
[1] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dunedin 9016, New Zealand
[2] Univ Otago, Fac Dent, Dept Oral Diagnost & Surg Sci, 310 Great King St, Dunedin 9016, New Zealand
[3] Univ Otago, Fac Dent, Dept Oral Sci, 310 Great King St, Dunedin 9016, New Zealand
来源：
GENES | 2023年 / 14卷 / 02期
关键词：
cytoskeleton; Rho-kinase; ROCK; Rho-associated coiled-coil forming kinase; DEPENDENT PROTEIN-KINASE; GLYCOGEN-SYNTHASE KINASE-3; INTERMEDIATE-FILAMENT PROTEINS; ACTIN CYTOSKELETON; SMOOTH-MUSCLE; BETA-CATENIN; MICROTUBULE DYNAMICS; CELL-MIGRATION; NUCLEAR LAMINS; P38; MAPK;
D O I：
10.3390/genes14020272
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is a complex and dynamic network composed of microfilaments, intermediate filaments and microtubules. These cellular structures confer both cell shape and mechanical properties. The architecture of the networks formed by the cytoskeleton is regulated by several pathways, a key one being the Rho-kinase/ROCK signaling pathway. This review describes the role of ROCK (Rho-associated coiled-coil forming kinase) and how it mediates effects on the key components of the cytoskeleton that are critical for cell behaviour.
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页数：20
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