Late Midlife Subclinical Infarct Burden and Risk of Dementia: The Atherosclerosis Risk in Communities Neurocognitive Study

被引：1

作者：

Sullivan, Kevin J. ^{[1
]}

Griswold, Michael E. ^{[1
]}

Ghelani, Kunali ^{[1
]}

Rajesh, Aishwarya ^{[2
]}

Shrestha, Srishti ^{[1
]}

Gottesman, Rebecca F. ^{[3
,4
]}

Knopman, David ^{[5
]}

Mosley, Thomas H. ^{[1
]}

Windham, B. Gwen ^{[1
]}

机构：

[1] Univ Mississippi, Med Ctr, Memory Impairment & Neurodegenerat Dementia Ctr, Jackson, MS 39216 USA

[2] Univ Mississippi, Dept Psychiat & Human Behav, Med Ctr, Jackson, MS USA

[3] NINDS, Bethesda, MD 20892 USA

[4] NIH, Stroke Intramural Program, Bethesda, MD 20892 USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 91卷 / 02期

关键词：

Cerebrovascular disease; cognition; dementia; epidemiology; infarct; SMALL VESSEL DISEASE; COGNITIVE FUNCTION; MICROINFARCTS;

D O I：

10.3233/JAD-220746

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

At visit 3 (1993-1995) of the ARIC Study, 1.5T brain MRI was completed in 1,881 stroke-free participants (Mean age = 62.9 +/- 4.9, 50% Black). Cox regression examined associations between infarct group [infarct-free (referent; n = 1,611), smaller only (<3 mm; n = 50), larger only (>= 3mm but <20 mm; n = 185), both (n = 35)] and up to 25-year incident dementia (n = 539). Participants with both infarcts were over 2.5 times more likely to develop dementia [HR = 2.61; 95%CI = 1.44, 4.72]. Smaller only (HR = 1.22; 95%CI = 0.70, 2.13) and larger only (HR = 1.27; 95%CI = 0.92, 1.74) groups showed associations with wide confidence intervals, unsupported statistically. A late midlife infarct profile including smaller and larger infarcts may represent particular vulnerability to dementia risk.

引用

页码：543 / 549

页数：7

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